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| 尼美舒利口腔崩解片的制备及质量检查 | |
| 引用本文： | 张湛睿,王树春,魏振平. 尼美舒利口腔崩解片的制备及质量检查[J]. 西北药学杂志, 2006, 21(6): 261-263 |
| 作者姓名： | 张湛睿 王树春 魏振平 |
| 作者单位： | 1. 陕西医学高等专科学校,陕西,西安,710068;天津大学化工学院,天津,300072 2. 陕西医学高等专科学校,陕西,西安,710068 3. 天津大学化工学院,天津,300072 |
| 摘 要： | 目的制备尼美舒利口腔崩解片。方法采用正交设计筛选尼美舒利口腔崩解片的处方并考察片剂质量。结果由15％乳糖、20%微晶纤维素、30％PVPP、1％CMS-Na组成的优化处方所制备的口腔崩解片口感良好,在45 s内完全崩解,10min释药97 %以上。结论该口腔崩解片处方合理、质量可控。 |
| 关 键 词： | 尼美舒利 口腔崩解片 正交试验 质量检查 |
| 文章编号： | 1004-2407（2006）06-0261-03 |
| 收稿时间： | 2006-02-10 |
| 修稿时间： | 2006-02-10 |
Preparation and Quality Control of Nimesulide Orally Disintegrating Tablets |
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| ZHANG Zhan-rui,WANG Shu-shun,WEI Zhen-ping. Preparation and Quality Control of Nimesulide Orally Disintegrating Tablets[J]. Northwest Pharmaceutical Journal, 2006, 21(6): 261-263 | |
| Authors: | ZHANG Zhan-rui WANG Shu-shun WEI Zhen-ping |
| Abstract: | Objective To study the preparation and quality control methods of Nimesulide Orally Disintegrating Tablets. Methods The orthogonal design was used to optimize the formulation of Nimesulide Orally Disintegrating Tablets,and quality of prepared tablets was examined. Results Besides Nimesulide,the tablets were composed of lactose 15% ,20% ,PVPP 30% ,CMS-Na 1%. The prepared tablets disintegrated completely in 40s, dissolved more than 97% in 10min and taste fine. Conclusion The preparation and quality control methods of Nimesulide Orally Disintegrating Tablets is suitable. |
| Keywords: | Nimesulide Orally Disintegrating Tablets orthogonal design quality evaluation |
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