Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study |
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| Authors: | A Honig L Rieger M Kapp M Krockenberger M Eck J Dietl U K?mmerer |
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| Affiliation: | (1) Dept. of Obstetrics and Gynecology, University of Wuerzburg, Germany;(2) Dept. of Pathology, University of Wuerzburg, Germany |
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| Abstract: | Background Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as a marker of bone disease in breast cancer patients, we observed high concentrations of TRAP even in patients without bone metastases. To elucidate this phenomenon, we examined the expression of TRAP in breast cancer cells and the cells of several other malignancies. |
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