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| 急性淋巴细胞性白血病患儿化疗前后CYP3A酶活性研究 | |
| 引用本文： | 张健,唐跃年,刘海涛,陈伦,袁晓军,顾龙君,蒋新国. 急性淋巴细胞性白血病患儿化疗前后CYP3A酶活性研究[J]. 中国药师, 2007, 10(2): 110-112 |
| 作者姓名： | 张健 唐跃年 刘海涛 陈伦 袁晓军 顾龙君 蒋新国 |
| 作者单位： | 1. 上海复旦大学药学院 上海 200032 2. 上海交通大学医学院附属新华医院药剂科 3. 上海交通大学医学院附属新华医院儿童医学中心血液科 |
| 摘 要： | 目的:探索急性淋巴细胞性白血病(ALL)患儿体内CYP3A酶活性与正常儿童群体间的差异及化疗前后患儿对CYP3A酶活性影响。方法:测定尿中6β-羟基氢化可的松与氢化可的松比值,计算体内CYP3A酶活性。结果:ALL患儿化疗前CYP3A酶活性明显高于化疗后酶活性,也显著高于正常儿童酶活性(P<0.05)。结论:ALL患儿化疗前后体内CYP3A酶活性差异极大。 |
| 关 键 词： | 急性淋巴细胞性白血病 6β-C/C 探针 化疗 |
| 文章编号： | 1008-049X(2007)02-0110-03 |
| 修稿时间： | 2006-06-06 |
Study on Activity of CYP3A in the Children with Acute lymphoblastic leukemia Before and After Therapy |
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| Zhang Jian,Tang Yuenian,Liu Haitao,Chen Lun,Yuan Xiaojun,Gu Longjun,Jiang Xinguo. Study on Activity of CYP3A in the Children with Acute lymphoblastic leukemia Before and After Therapy[J]. China Pharmacist, 2007, 10(2): 110-112 | |
| Authors: | Zhang Jian Tang Yuenian Liu Haitao Chen Lun Yuan Xiaojun Gu Longjun Jiang Xinguo |
| Affiliation: | 1. School of pharmacy, Shanghai Fudan University, Shanghai 200032, China; 2. Department of Pharmacy, Affililiated Xinhua Hospital, Medical college Shanghai Jiaotong University; 3. Department of Pediatrics, Shanghai Childrent Medical Center, Affiliated Xinhua Hospital, Medical college Shang- hai Jiao Tong University |
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