| 肝硬化与肝癌患者外周血T淋巴细胞表面受体表达变化的研究 |
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| 引用本文： | 唐望先,张文英,李绍白,李品兰.肝硬化与肝癌患者外周血T淋巴细胞表面受体表达变化的研究[J].华中科技大学学报(医学版),1991(Z1). |
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| 作者姓名： | 唐望先 张文英 李绍白 李品兰 |
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| 作者单位： | 同济医科大学肝病研究所
(唐望先，张文英，李绍白)，同济医科大学实验医学研究中心免疫室(李品兰) |
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| 摘 要： | 作者应用单克隆抗体检测肝硬化、肝癌病人外周血T淋巴细胞表面受体表达的变化。其中肝硬化(LC)、肝癌(PHC)组的CD_8的阳性细胞分别是34.72％、38.93％,正常对照组为27.30％,与正常组比较,P<0.01。两组CD_4/CD_8比值显著下降,其比值分别为1.29、1.31,正常组1.8,与正常组比较,P<0.01。PHA刺激前,转铁蛋白受体(TFR)和白细胞介素-2受体(IL-2R)在两组患者血中处于高表达状态(P<0.01)。结果提示:抑制性TC升高,TFR以及IL-2R的高表达则直接影响LC和PHC的预后。
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| 关 键 词： | 肝硬变 肝癌 受体 转铁蛋白 受体 白细胞介素-2 |
A Study of T Cell Subsets, Transferrin Receptor and Interleukin-2 Receptor in Liver Cirrhosis and Primary Hepatocellular Carcinoma |
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| Tang Wangxian,Zhang Wenying,Li Shaobai Institute of Liver Diseases,Tongji Medical University,WuhanLi PinlanImmunology Research Unit,Research Centre of Experimental Medicine,Tongji Medical University,Wuhan.A Study of T Cell Subsets, Transferrin Receptor and Interleukin-2 Receptor in Liver Cirrhosis and Primary Hepatocellular Carcinoma[J].Journal of Huazhong University of Science and Technology(Health Sciences),1991(Z1). |
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| Authors: | Tang Wangxian Zhang Wenying Li Shaobai Institute of Liver Diseases Tongji Medical University WuhanLi PinlanImmunology Research Unit Research Centre of Experimental Medicine Tongji Medical University Wuhan |
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| Abstract: | The changes of T cell subsets and the expression of Transferrin receptor (TFR) and Interleukin-2 receptor (IL-2) of peripheral blood were studied in patients with liver cirrhosis(LC)and primary hepatocellular carcinoma (PHC).The results showed that CD8 cells in patients with LC and PHC increased to 34.72% and 38.93%respectively.The ratio of CD4/CD8 significantly decreased in twe groups of patients to 1.29 and 1.31, respectively, while that of normal group was 1.8 (P< 0.01). Our data also showed that TFR and IL-2R were in a state of high-expression in resting T cells but no marked changes could be found in the receptor expression of PHA-stimulated T cells of patients, as compared with the control group. From the foregoing it may be suggested that prognosis of LC and PHC is influenced by inhibitory T cells and high expression of TFR and IL-2R. |
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| Keywords: | liver cirrhosis primary hepatocellular carcinoma receptor trans-ferrin receptor interleukin-2 |
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