正常高值血压及其合并的传统危险因素与同型半胱氨酸的关系

目的 探讨同型半胱氨酸（Hcy）与正常高值血压（高血压前期）及其合并的传统危险因素之间的关系,以利于早期干预血压进展和靶器官损害.方法 随机选取我院体检中心正常高值血压者300例为研究组;选择107例同期健康体检血压正常者为对照组.计算体重指数（BMI）,测定空腹血糖（FPG）、血清总胆固醇（CHO）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血红蛋白（Hb）、尿酸（UA）和Hcy（酶法）,并做比较和相关性分析.将正常高值血压组进一步分为正常高值血压合并高血糖组和正常高值血压合并代谢综合征组,并做组内比较.结果 正常高值血压组血清Hcy显著高于对照组（18.03±11.13）μmol/L比（13.21±5.81）μmol/L]（P〈0.05）.Hcy与血压、BMI、TG、UA、Hb呈正相关,与HDL-C呈负相关,与年龄、FPG、CHO、LDL-C无关联,且存在性别差异（男性〉女性）.正常高值血压组组内比较Hcy差异无统计学意义.结论 ①正常高值血压者Hcy水平高于正常血压者,且血清Hcy浓度越高,血压水平和尿酸越高.检测Hcy有利于早期干预血压进展和靶器官损害.②合并的传统危险因素并不增加Hcy,Hcy与进一步增加的心血管危险无直接相关.

The association of high-normal blood pressure clustered established risk factors with homocysteine

Objective This study was performed to investigate the relationship between high-normal blood pressure（pre-HTN）clustered established risk factors and homocysteine（Hcy）. Hopefully, it could benefit the early intervention with blood pressure development and target organ damagement（TOD）. Methods 300 high-nor- mal blood pressure individuals （120-139/80-89 mm Hg）and 107 normal blood pressure individuals（〈120/80mm Hg）were occasionally selected from the people who are fit for the critia. And the former was studied as study group when the latter as control group. The body mass index （BMI）,fasting plasma glucose （FPG）,total cholesterol （CHO）, triglyceride （TG）, high-density lipoprotein cholesterol （ HDL-C ）, low-density lipoprotein cholesterol （ IA）L- C ）, hemoglobin （Hb）, uric acid （ UA ）, Hcy （by enzymatic method ）were measured and compared between the normal blood pressure and high-normal blood pressure groups.And then, correlationed the risk factors with Hcy.We subse- qently categorized the study group two times.Pre-HTN complicated hyperglycemia and pre-HTN complicated metabolic syndrome were studied as study group, respectively.Then, compared by Hcy. Results The Hcy value in the pre-HTN group was higher than the control group （ 18.03± 11.13 ）umol/L vs （ 13.21±5.81 ）umo/L, （P〈0.05） ]. Spearman correlation analysis showed Hcy correlated positively with blood pressure,BMI,TG,UA ,Hb,negatively with HDL-C .However, Age, FPG, CHO, LDL-C were not correlated with Hcy.In addition, we fould the differencemerit between male and female （male〉female）.However,we didn＇t find Hcy statistic significance when pre-HTN complicated hyperglycemia and pre-HTN complicated metabolic syndrome were compared with there counterpart. Conclusion （1）Compared with group of normal blood pressure, high-normal blood pressure group have higher Hcy leval.And with the Hcy rising, the BP and UA leval have increased.Therefore, supervising Hcy benefites BP-control and TOD-relievement at early state. （2）With the established risk factors rising, Hcy leval hasn＇t correspondingly increased. And Hcy hasn＇t direct influence with the further cardiovascular risk rising.