药物滥用者机体免疫功能损伤机制探讨

WedetectedtheperipheralbloodindexesofsubgroupsofThcells，transformationrateoflymphocytes，IgA，IgM，IgG，IgE，complimentC３，C４，IL－１，IL－６，TNFandNOin５０drugabusersandsuggestedthemechanismofimmunefunctioninjuryinthem．１Subjectsandmethods１．１SubjectsThetestgroupcomprisedof５０confirmeddrugabusersadmittedbytheDongpolingAbstinenceCenterofZhanjiangPublicSafetyBureauincluding３０malesand２０females，aging１８～３７yearsmeanly（２６．４０±４．６８）years．Allofthemweredrugabuse…

The immune function injury and its mechanism in drug abuser

Objective To explore the immune function injur y and its mechanism in drug abuser.Methods The immune function changes in50drug abusers were compared with normal healthy populations by detection of the indexes of subgroups of Th cells,transformation rate of lymphocytes,IgA,IgM,IgG,IgE,com pliment C 3 ,C 4 ,IL-1,IL-2,IL-6TNF and NO.Result In peripheral blood the percentage o f Th 1 cell,transformation rate of lymphocyte,IgA,IgM,IgG,IgE content,complime nt C4,C4,IL-1,IL-2,IL-6,and TNF le vels were significantly lower than normal (P <0.01).The value of Th 1 /Th 2 was lower than normal as well(P <0.05).NO content was significantly higher than normal (P <0.001).Conclusion The mechanism of immune function inj ury in drug abuser might be correlative to direct injury of drugs and their inhibition effect on the thymu s-hypothalamus-hypophysis-adren al axis.