右美托咪啶于患者全麻状态下围拔管期血液动力学的影响

目的观察右美托咪啶于全麻状态下围拔管期血流动力学的影响,尤其在用于合并Ⅰ、Ⅱ期高血压基础疾病患者全麻气管拔管的应用效果及安全性。方法患者150例,随机分为观察组(右美托咪啶组)和对照组(生理盐水组)各75例,比较两组患者在拔管前、拔管时、拔管后即刻、拔管后各时间段患者的心率、血压变化情况。结果 (1)观察组各时段心率(HR)、收缩压(SBP)、舒张压(DBP)比较差异均无统计学意义(P>0.05),对照组拔管时、拔管后即刻、拔管后5 min及10 min均有部分指标与拔管前差异有统计学意义(P<0.05)。(2)观察组给予右美托咪啶静脉滴注后出现低血压1例,口干1例,不良反应均较轻微,停药后2 d内均消失。结论患者处于围拔管期,其血流动力学方面会有较大波动,尤其在有基础高血压的患者更表现明显,右美托咪啶用于Ⅰ、Ⅱ期高血压患者全麻气管拔管可以起到稳定血流动力学作用,且临床用药安全性较高。

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Objective Observe of the right Dexmedetomidine in anesthesia,tracheal extubation under the influence of hemodynamics.Methods 150 patients withⅠ,Ⅱ hypertension were selected and put into two groups as Dexmedetomidine group and saline group during Jan 2009 to Sep 2010 in our hospita,and before extubation,tracheal extubation,after extubation,after extubation,the time heart rate,blood pressure changes were observed.Results Heart rate observed group sessions(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP) showed no significant difference(P>0.05),the control group extubation,after extubation after extubation 5min and 10min before extubation were part of the index and significantly different(P<0.05).Conclusion Dexmedetomidine for stage Ⅰ,Ⅱ hypertension tracheal extubation can Play a role in stabilizing hemodynamics,and clinical drug safety is high;Blood dynamics;influence.