红外期疟疾疫苗的研究进展 |
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引用本文: | 彭小红.红外期疟疾疫苗的研究进展[J].成都医学院学报,2011,6(2):118-123. |
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作者姓名: | 彭小红 |
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作者单位: | 第三军医大学基础部病原生物学教研室,重庆,400038 |
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摘 要: | 红外期是疟原虫侵入宿主的第一个时期,有效的红外期疟疾疫苗对控制疟疾的发病和流行具有重要的作用.目前研究中的红外期疟疾疫苗主要有亚单位疫苗和全虫疫苗两种,其中后者包括了放射减毒子孢子疫苗和基因减毒子孢子疫苗.全虫疫苗虽然能够诱导完全性的免疫保护作用,但是其生产及运输方式却限制了它的现场应用.目前的亚单位疫苗不能达到让人满...
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关 键 词: | 疟疾 红外期 疫苗 |
Advances in pre-erythrocytic stage malaria vaccine |
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Authors: | PENG Xiao-hong |
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Institution: | PENG Xiao-hong,HUANG Fu-sheng(Department of Pathogenic Biology,Third Military Medical University,Chongqing 400038,China) |
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Abstract: | Pre-erythrocytic stage is the first stage which Plasmodium to invaded a human host,effective malaria vaccine for pre-erythrocytic stage has important significance to control the morbidity and the prevalence of the malaria.The present study of malaria vaccines for pre-erythrocytic stage include subunit vaccines and whole-cell vaccines,the latter is also included irradiation-attenuated sporozoites and genetically attenuated sporozoites.Although whole-cell vaccines induce complete and long-lasting protection,the difficulties to produce and transport have limited its clinical application.The current subunit vaccines are still not achieve satisfactory protective effect,and the relevant mechanisms need further in-depth study.Here,we do a review on the development of these vaccines. |
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Keywords: | Malaria pre-erythrocytic stage vaccine |
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