中国HIV/AIDS患者CD+4 CD+8T淋巴细胞与外周血各组份间关系的研究

目的研究艾滋病病毒/艾滋病(HIV/AIDS)患者CD+4、CD+8T淋巴细胞数与外周血各组份间白细胞(WBC)、血小板(PLT)、血红蛋白(HGB)、粒细胞百分数(GR%)、淋巴细胞百分数(LY%)、LY的相关性,为临床治疗提供参考依据.方法HIV/AIDS患者抗凝外周血513份,在6小时之内检测其血细胞分类和CD+4、CD+8T淋巴细胞计数,比较CD+4、CD+8T淋巴细胞计数与WBC、HGB、PLT、LY%、GR%和LY的相关性.结果CD4/CD8全部倒置,其中CD4/CD8＜1者达94.7%;CD+4细胞数＜500/mm3与HGB(r＝0.160,P＜0.01)、PLT(r＝-0.014,P＜0.01)、GR%(r＝-0.281,P＜0.01)、LY%(r＝0.321,P＜0.01)、LY((r＝0.494,P＜0.01)相关均有非常显著的统计学意义;CD+8细胞数与WBC数(r＝0.112,P＜0.05)、HGB(r＝0.131,P＜0.01)、GR%(r＝-0.526,P＜0.01)、LY%(r＝0.569,P＜0.01)、LY(r＝0.904,P＜0.01)相关均有显著性;200/mm3＜CD+4细胞数＜500/mm3与LY(r＝0.279,P＜0.01)、PLT(r＝0.192,P＜0.01)相关有显著性,CD+4细胞数＜200/mm3与LY(r＝0.262,P＜0.01)、LY%(r＝0.279,P＜0.01)、GR%(r＝-0.294,P＜0.01)相关有显著性.结论HIV/AIDS患者CD+4、CD+8T淋巴细胞数与外周血中HGB、LY%、LY呈正相关,与GR%呈负相关.CD4/CD8与HGB、PLA、LY相关无显著性.

Study on the relationship between values of CD4,CD8 and the components of peripheral blood in people living with HIV/AIDS in China

Objective To study the relationship between values of CD 4,CD 8 and the components of peripheral blood(WBC,PLT,HGB,GR%,LY%,LY)in people living with HIV/AIDS(PLWHA)and to provide scientific basis for clinical treatment.Method Five hundred and thirteen samples of peripheral anticoagulated blood collected from PLWHA were examined for their respective components of blood cells and CD 4,CD 8 cell counts within 6 hours to investigate the relationship between values of CD 4,CD 8 and WBC,HGB,PLT,LY%,GR% and LY.Result CD 4 cell counts below 500/mm 3 were significantly correlated with HGB r=0.160(P<0.01), PLT r=-0.014(P<0.01), GR% r=-0.281(P<0.01), LY% r=0.321(P<0.01), LY r=0.494(P<0.01); CD 8 cell counts were significantly correlated with WBC r=0.112(P<0.05), HGB r=0.131(P<0.01), GR% r=-0.526(P<0.01) ,LY% r=0.569(P<0.01), LY r=0.904(P<0.01); CD 4 cell counts between 200/mm 3 and 400/mm 3 were significantly correlated with LY r=0.279(P<0.01) and PLT r=0.192(P<0.01); CD 4 cell counts below 200/mm 3 were significantly correlated with LY r=0.262(P<0.01), LY% r=0.279(P<0.01) and GR% r=-0.294(P<0.01); CD 4/CD 8 were all reversed,and CD 4/CD 8 below 1 accounted for 94.7%.Conclusion CD 4 and CD 8 cell counts were positively correlated with HGB,LY%,and LY in peripheral blood from PLWHA and were negatively correlated with GR%;CD 4/CD 8 were not signifi-cantly correlated with HGB,PLA or LY.