| 左旋肉碱对维持性血液透析患者氧化应激的影响 |
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| 引用本文： | 刘伦志.左旋肉碱对维持性血液透析患者氧化应激的影响[J].湖北民族学院学报(医学版 ),2006,23(3):31-33. |
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| 作者姓名： | 刘伦志 |
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| 作者单位： | 湖北民族学院附属医院肾内科,湖北,恩施,445000 |
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| 摘 要： | 目的 观察左旋肉碱对维持性血液透析患者氧化应激的影响.方法 38例维持性血液透析患者随机分为对照组(n=20)和肉碱治疗组(n=18).肉碱治疗组除给予和对照组相同的维持性血液透析治疗外,在每次透析结束时给予左旋肉碱1.0g静脉注射,治疗4周后测定患者血清总抗氧化能力(TAOC)、超氧化物歧化酶(SOD)、丙二醛(MDA).结果 维持性血液透析患者给予肉碱治疗后TAOC、SOD较对照组上升(P＜0.05),MDA浓度较对照组显著下降.结论 左旋肉碱能增强维持性血液透析患者抗氧化应激能力.
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| 关 键 词： | 左旋肉碱 维持性血液透析 氧化应激 |
| 文章编号： | 1008-8164(2006)03-0031-02 |
| 收稿时间： | 2006-07-15 |
| 修稿时间： | 2006年7月15日 |
Effect of Levocarnitine on Oxidative Stress in Maintenance Hemodialysis Patients |
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| LIU Lun-zhi.Effect of Levocarnitine on Oxidative Stress in Maintenance Hemodialysis Patients[J].Journal of Hubei Institute For Nationalities(Medical Edition),2006,23(3):31-33. |
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| Authors: | LIU Lun-zhi |
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| Institution: | Department of Nephrology, Affiliated Hospital of Hubei Intitute for Nationalities, Enshi 445000, China |
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| Abstract: | Objective To observe the effect of Levocarnitine on oxidative stress in maintenance hemodialysis patients.Methods thirty eight maintenance hemodialysis patients were randomly divided into control group group(n=20) and Levocarnitine therapy group(n=18),The Levocarnitine therapy group were injected Levocarnitine 1.0 g after every hemodialysis.The total antioxidant capacity(TAOC),superoxide dismutase(SOD) and malondialdehyde(MDA)were determined after four weeks.Results Compared with control group,the TAOC and SOD were higher in Levocarnitine therapy group(P<0.05),and the MDA was significantly lower than control group group(P<0.05).Conclusion Levocarnitine can enhance antioxidative in maintenance hemodialysis patients. |
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| Keywords: | Levocarnitine Maintenance hemodialysis Oxidative Stress |
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