运动性横纹肌溶解高反应者ACE／CK—MM基因多态性分析

目的探讨中国汉族运动性横纹肌溶解（ERB）高反应者（HR）ACE基因I／D多态性及肌酸肌酶（CK）-MM基因限制性酶切片段多态性的分布特点。方法采用PCR及限制性酶切多态性分析技术，对12例中国汉族ERBHR的ACE、CK-MM基因多态性进行检测、分析。结果本组12例ERBHR的ACE基因频率I为54％、D为46％，D等位基因频率较汉族正常人群高，但无统计学意义（P=0．146）；汉族正常人群与高加索正常人群相比，P〈0．01。本组ERBHR的CK-MM基因频率A为71％、G为29％，G等位基因频率较汉族正常人群高，但无统计学意义（P=0．078）；汉族正常人群与高索ERBHR的该基因频率高度一致（P=0．992）。结论汉族ERBHR人群ACED、CK-MMG等位基因频率均稍高于汉族正常人群。

Analysis of ACE/CK-MM gene polymorphism with high responder of exertional rhabdomyolysis

Objective To investigate the distribution polymorphism of ACE gene and CK-MM gene in high responder （HR） of exertional rhabdomyolysis（ERB） of Chinese Hart population in china. Methods The polymerase chain reaction and the restriction fragment length polymorphism （PFLP） were used to examine genotype and allele frequencies of 12 cases of ERB HR. Results The allele frequencies of ACE gene in ERB HR were I =54%, D =46%. The frequence of D allel of ERB HR was higer than that of Han control, but no difference in statistics （P = 0. 146）, the Han controls were significant difference with Caucasian（ P 〈 0. 01 ）. The CK-MM NcoI allele frequencies of Han were A = 71%, G = 29%. The frequence of G allel of ERB HR was higer than that of Han controls, but no difference in statistics （ P = 0.078）, the CK-MM gene freguencies of Hart controls almost consistent with ERB HR of Caucasian（ P =0.992）. Conclusion The ACE D and CK-MM G of Hart ERB HR is higher than that of Han controls.