| 利福平和异烟肼联用的药物动力学研究 |
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| 引用本文： | 邓立东,蒋学华,邓航,卢来春,贾运涛,李素华. 利福平和异烟肼联用的药物动力学研究[J]. 华西药学杂志, 2003, 18(1): 16-19 |
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| 作者姓名： | 邓立东 蒋学华 邓航 卢来春 贾运涛 李素华 |
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| 作者单位： | 1. 桂林医学院附属医院,广西,桂林,541001
2. 四川大学华西药学院,四川,成都,610041 |
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| 摘 要： | 目的 探讨利福平和异烟肼联用的体内药物动力学规律。方法 采用两种给药方法双周期交叉试验设计，比较联合给药与单独给药的动力学参数。结果 利福平和异烟肼联合给药末见药物间的相互作用。结论 利福平和异烟肼联合给药与单用时的药物动力学无显著差异。
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| 关 键 词： | 利福平 异烟肼 联合给药 单独给药 药物动力学 比较 相互作用 |
| 文章编号： | 1006-0103(2003)01-0016-04 |
| 修稿时间： | 2002-06-01 |
Study on pharmacokinetics of Rifampin and Isoniazid administered in combination |
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| DENG Li-dong ,JIANG Xue-hua ,DENG Hang ,LU Lai-chun ,JIA Yun-tao ,LI Su-hua. Study on pharmacokinetics of Rifampin and Isoniazid administered in combination[J]. West China Journal of Pharmaceutical Sciences, 2003, 18(1): 16-19 |
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| Authors: | DENG Li-dong JIANG Xue-hua DENG Hang LU Lai-chun JIA Yun-tao LI Su-hua |
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| Affiliation: | DENG Li-dong 1,JIANG Xue-hua 2,DENG Hang 1,LU Lai-chun 2,JIA Yun-tao 2,LI Su-hua 2 1.Affiliated Hospital of Guilin Medical College,Guilin 541001,China,2.West China School of Pharmacy,Sichuan University,Chengdu 610041,China |
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| Abstract: | OBJECTIVE To investigate pharmacokinetics of Rifampin and Isoniazid administered in combination by animal tests.METHODS Cross-over randomized design(two-two periods, two preparations) was employed One group was supplied with INH or RFP individually,while the other was supplied with INH and RFP in combination, and pharmacokinetic parameters were calculated and compared.RESULTS The interaction of RFP and INH did not affect the pharmacokinetics of each other.CONCLUSION There is no significant difference in pharmacokinetics of RFP and INH after administrated individually and in combination. |
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| Keywords: | Rifampin Isoniazid Administered in combination Interaction Pharmacokinetics |
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