基于蛋白组学的子宫内膜容受性研究进展

目前评价子宫内膜容受性手段很多,但价值有限。蛋白组学作为一门高通量的新技术,已经被很多学者用于筛查子宫内膜容受性的分子生物学标志。通过比较子宫内膜蛋白谱从增生期到分泌期、从种植前期到种植窗期动态变化过程,学者们鉴定出了一系列与子宫内膜容受性相关的蛋白。内膜分泌蛋白组学作为一种崭新的无创性评估内膜容受性的方法,在未来子宫内膜容受性标志分子筛选中具有强大的应用价值。

Current progress in receptivity of endometrium based on proteomics

There are plenty of means to evaluate endometrial receptivity at present, but of limited value.As a new high-throughput technology, proteomics has been used for screening the molecular marker of endometrial receptivity. A series of proteins related with endometrial receptivity have been identified by comparing the dynamic change of protein profiles from the proliferative phase to the secretory phase, and from the prereceptive phase to the receptive phase. As a new method to noninvasively evaluate endometrial receptivity, endometrial secretion proteomics has a powerful application value for screening the molecular marker of endometrial receptivity.