兔坐骨神经实验性电损伤后形态学变化

目的：观察在不同损伤电压情况下，神经轴突超微结构的变化。方法：在兔梨状肌以远分别用５０，７５，２００Ｖ交流电损伤３ｃｍ坐骨神经，然后在１ｗｋ，２ｗｋ，１ｍｏ，３ｍｏ时切取神经组织标本在透射电镜下观察神经纤维超微结构变化。结果：５０Ｖ损伤组２ｗｋ时形态改变轻微，１ｍｏ时神经结构恢复正常。７５Ｖ损伤组２ｗｋ时神经纤维损伤程度加重，１ｍｏ时可见有新生纤维，３ｍｏ时变性纤维数目减少，新生纤维结构趋于成熟。

Morphological changes of the sciatic nerve of rabbits after electrical injury

AIM: The ultrastructure of sciatic nerve injured by electric current was observed under the electron microscopy. METHODS: The sciatic nerve was injured by 50 V, 75 V and 200 V alternating current. The ultrastructure of the neurites was observed under the transmission electron microscopy in 1 wk, 2 wk, 1 mo and 3 mo. RESULTS: In the 50V injury group, the morphological structure was destroyed mildly in 2 weeks, and restored to normal in 1 mo. In the 75 V injury group, the injury aggravated in 2 weeks, but the regenerative nerve fibers could be seen in 1 mo and the degenerative nerve fibers decreased. The regenerative nerve fibers became mature in 3 mo. In the 200 V injury group, the ultrastructure of nerve fibers was destroyed severely. There was thrombosis in the blood vessels. The content of collagen fibers that blocked the regenerative fibers increased. CONCLUSION: The destruction of ultrastructure of nerve fibers is positively correlated to the force of the electrical current: The higher the electrical current, the severely. The fibrosis aggravated and the regenerative nerve fibers were inhibited.