阿托伐他汀联合坎地沙坦治疗血脂正常老年单纯收缩期高血压临床评价

【目的】研究阿托伐他汀对血脂正常的老年单纯收缩期高血压（ISH）患者的降压疗效、危险因素控制和安全性。【方法】入选的82例中危或高危老年ISH患者，随机分为治疗组（阿托伐他汀联合坎地沙坦和氢氯噻嗪）和对照组（坎地沙坦联合氢氯噻嗪），观察8周，用药前后测量24h动态血压，计算血压平滑指数（SI），生化及超声检查，观察临床指标及不良反应。【结果】治疗组降压疗效优于对照组（P〈0．05），SI治疗组优于对照组（P〈0．05）。【结论】阿托伐他汀对血脂正常的老年ISH患者具有降压作用，其作用与阿托伐他汀延缓动脉粥样硬化（AS）进程，控制血管内皮炎性反应有密切关系。

Clinical Study on the Effect of Atorvastatin on Senile Hypertension without Hyperlipidemia

Objective] To observe the effect of atorvastatin on isolated systolic hypertension （ISH） of se- nile patients without hyperlipidemia. MethodslEighty two senile ISH patients without hyperlipemia enrolled in this study were randomly divided into two groups. The treatment group （n = 41） received atorvastatin 20mg/d and candesartan-hydrochlorothiazide. The control group （n = 41） received candesartan-hydrochlorothiazide. The observation was undergone for 4 weeks before and after administration of atorvastatin. The 24h ambulatory blood pressure was measured and blood pressure stable index （SI） was calculated. Biochemical and ultrosonography examination were done. Clinical parameters and side effects were observed. Resultsl The hypotensive effect in the treatment group was superior to the control group （ P 〈0. 05）. And SI in the treatment group was also better than,that in the control group （ P 〈0. 05）. Conclusionl Atorvastatin has hypotensive effect on senile ISH patients without hyperlipidemia. It may play a role in delaying the progression of artherosclerosis and controlling the inflammation response of vascular endothelium.