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| 羟喜树碱脂质体中药物对磷脂稳定性的影响 | |
| 引用本文： | 刘文一,谢俊,周建平,严拯宇.羟喜树碱脂质体中药物对磷脂稳定性的影响[J].药学与临床研究,2009,17(4):306-308. |
| 作者姓名： | 刘文一 谢俊 周建平 严拯宇 |
| 作者单位： | 1. 中国药科大学,分析教研室,南京,210009;中国药科大学,药剂教研室,南京,210009 2. 金陵药业股份有限公司技术中心,南京,210009;中国药科大学,药剂教研室,南京,210009 3. 中国药科大学,药剂教研室,南京,210009 4. 中国药科大学,分析教研室,南京,210009 |
| 摘 要： | 目的:通过对磷脂水解产物溶血磷脂(LPC)的测定,对比空白脂质体与含药脂质体中溶血磷脂含量变化,系统研究了羟喜树碱脂质体中药物对脂质体稳定性的影响.方法:通过高温加速试验的方法,对HCPT脂质体中LPC含量的变化进行比较性研究,并采用HPLC-ELSD法对其含量进行准确测定.结果:经加速试验后发现,含药脂质体中LPC的百分含量较空白脂质体增加10%,两者存在显著性差异(P＜0.05).结论:HCPT脂质体中药物对磷脂水解过程有明显的催化作用,建议在此类药物的研发中应高度关注. |
| 关 键 词： | 溶血磷脂 磷脂 水解 羟喜树碱 脂质体 |
| 收稿时间： | 2009/3/23 0:00:00 |
10-Hydroxycamptothecin-catalyzed phospholipid hydrolysis in liposome |
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| LIU Wen-yi,XIE Jun,ZHOU Jian-ping and YAN Zheng-yu.10-Hydroxycamptothecin-catalyzed phospholipid hydrolysis in liposome[J].Pharmacertical and Clinical Research,2009,17(4):306-308. | |
| Authors: | LIU Wen-yi XIE Jun ZHOU Jian-ping and YAN Zheng-yu |
| Institution: | Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009;Research Institute of Jinling Pharmaceutical Co., Ltd., Nanjing 210009, China; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009;Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009 |
| Abstract: | Objective: Lysophosphatidylcholine (LPC), a hydrolysis product of phospholipids (PL), regulates a broad range of unfavourable cell processes. In hydroxycamptothecin (HCPT)-containing liposomes, the LPC concentrations were test to find out whether HCPT can impact the stability of this liposome. Methods: PL-hydrolysis in accelerated test was monitored by HPLC-ELSD with LPC quantified. The fluorescence properties of HCPT liposome and control liposome were also explored. Results: LPC in HPCT-containing liposomes increased 10% than that in control liposomes.Conclusion: HCPT has a catalytic effect on PL hydrolysis. The increase of lysophosphatidylcholine should be concerned in the storage of HCPT liposome. |
| Keywords: | Lyso-phosphatidylcholine Phospholipids Hydrolysis Hydroxycamptothecin Liposome |
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