| The effects of inosine and Ligusticum wallichii on ischemic injury of renal proximal tubule epithelial cells:cytochemical study |
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| 引用本文： | 沙继宏,郑尊. The effects of inosine and Ligusticum wallichii on ischemic injury of renal proximal tubule epithelial cells:cytochemical study[J]. 中国人民解放军军医大学学报, 1991, 0(2) |
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| 作者姓名： | 沙继宏 郑尊 |
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| 作者单位： | Central Laboratory Second Military Medical University，Shanghai 200433，Central Laboratory，Second Military Medical University，Shanghai 200433 |
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| 摘 要： | Cytochemical methods were used to evaluate the changes of intracellularcalcium,plasma membrane permeability and their relationship during ischemia andreflow in rat renal proximal tubule epithelial cells.In addition,the preventive ef-fects of inosine and Ligusticum wallichii on ischemia and reperfusion cell injurywere studied.The results showed that the preventive effects of inosine andLigusticum wallichii were obvious.Redistribution and slight increase of calciumoccurred during the ischemic period in the proximal tubule cells.In this periodthe changes of plasma membrane permeability were gentle.Following the exten-sion of reflow time,a large amount of calcium deposited in the cells andmitochondria.The plasma membrane became broken.There was a positivecorrelation between the calcium level in mitochondria and that in cytoplasm.
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The effects of inosine and Ligusticum wallichii on ischemic injury of renal proximal tubule epithelial cells:cytochemical study |
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| Sha Jihong Zheng Zun Central Laboratory,Second Military Medical University,Shanghai. The effects of inosine and Ligusticum wallichii on ischemic injury of renal proximal tubule epithelial cells:cytochemical study[J]. Journal of Medical Colleges of PLA(China), 1991, 0(2) |
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| Authors: | Sha Jihong Zheng Zun Central Laboratory Second Military Medical University Shanghai |
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| Affiliation: | Sha Jihong Zheng Zun Central Laboratory,Second Military Medical University,Shanghai 200433 |
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| Abstract: | Cytochemical methods were used to evaluate the changes of intracellular calcium,plasma membrane permeability and their relationship during ischemia and reflow in rat renal proximal tubule epithelial cells.In addition,the preventive ef- fects of inosine and Ligusticum wallichii on ischemia and reperfusion cell injury were studied.The results showed that the preventive effects of inosine and Ligusticum wallichii were obvious.Redistribution and slight increase of calcium occurred during the ischemic period in the proximal tubule cells.In this period the changes of plasma membrane permeability were gentle.Following the exten- sion of reflow time,a large amount of calcium deposited in the cells and mitochondria.The plasma membrane became broken.There was a positive correlation between the calcium level in mitochondria and that in cytoplasm. |
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| Keywords: | renal ischemia lanthanum cytochemistry EDX microanalysis calcium |
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