疏血通对急性脑梗死40例患者血P-、L-选择素表达及炎症的影响

目的：观察疏血通注射液对脑梗死患者P-、L-选择素表达及对炎症反应的影响，研究其干预脑缺血后炎症反应的环节及作用机制。方法：将诊断明确的急性脑梗死住院患者80例随机分为2组，治疗组40例，对照纽40例。对照纽给予西医常规治疗：抗血小板聚集、控制脑水肿、改善脑血循环、改善脑细胞代谢、防治并发症及支持疗法；治疗组在对照组的基础上加用0．9％生理盐水250mL＋疏血通注射液6mL，每天1次，连续使用14天。对比2组治疗前后临床疗效及P-、L-选择素及炎症指标C反应蛋白（CRP）的变化。结果：治疗组愈显率72．5％，有效率92．5％，高于对照组（50％和75％，P〈0．05）。治疗后2组患者临床神经功能缺损评分均有明显改善（P〈0．05），治疗组改善更明显（P〈0．05）；治疗后2组血P-、L-选择素、CRP均有明显改善（P〈0．05），治疗组在血P-、L-选择素、CRP的改善方面优于对照组（P〈0．05）。结论：疏血通注射液治疗急性脑梗死患者有较好的疗效，其作用机制与干预急性脑梗死患者P-、L-选择素的表达，调节炎症反应有关。

Impact of Shuxuetong on P- Selectin and L- Selectin Expression and Inflammation on 40 Patients with Acute Cerebral Infarction

Objective:To observe the impact of Shuxuetong on the expression of P-selectin,L-selectin,and C-reactive protein in the condition of acute cerebral infarction,and study the intervention mechanism thereof.Methods: Eighty patients were randomized to receive Shuxuetong(6ml,diluted with 250ml 0.9% Sodium Chloride,once per day) plus routine treatments(anti-platelet aggregation,etc.) for 14 consecutive days,controlled by those receiving the routine treatments only(anti-platelet aggregation,etc.).The clinical effec...