| 局麻药骨骼肌毒性作用的研究与临床意义 |
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| 引用本文： | 马冬梅,郑宏. 局麻药骨骼肌毒性作用的研究与临床意义[J]. 国际麻醉学与复苏杂志, 2009, 30(1). DOI: 10.3760/cma.j.issn.1673-4378.2009.01.018 |
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| 作者姓名： | 马冬梅 郑宏 |
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| 作者单位： | 新疆维吾尔自治区人民医院麻醉科,乌鲁木齐,830001;新疆医科大学第一附属医院麻醉科,乌鲁木齐,830001 |
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| 摘 要： | 最新研究证实,局麻药(locae anesthetic,LA)可导致骨骼肌损伤,甚至引起肌肉坏死,临床上使用的LA均存在骨骼肌毒性,因此将其对骨骼肌的损害视为局麻药的潜在并发症,但在临床上相关病例却很少见.现将近来国外对LA骨骼肌毒性的研究进展综述如下.
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| 关 键 词： | 局麻药 骨骼肌毒性 |
The study and clinical significance of local anesthetic myotoxicity |
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| MA Dong-mei,ZHENG Hong. The study and clinical significance of local anesthetic myotoxicity[J]. international journal of anesthesiology and resuscitation, 2009, 30(1). DOI: 10.3760/cma.j.issn.1673-4378.2009.01.018 |
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| Authors: | MA Dong-mei ZHENG Hong |
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| Abstract: | A lot of studies revealed that the local anesthetic may cause the degeneration of striated muscle sarcoplasmic reticulum and myocyte edema, even necrosis. All clinically used local anesthetics are myotoxic, with a drug-specific and dose-dependent rate of myotoxicity. We have to see local anesthetic myotoxicity as a potential complication. The molecular mechanism of local anesthetic myotoxicity are still not completely revealed. This articale reviews the recent related myotoxicity studies as follows. |
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| Keywords: | Local anesthetic Myotoxicity |
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