Oncogene HER-2 in Canine Mammary Gland Carcinomas |
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| Authors: | J. Martín de las Mulas J. Ordás Y. Millán V. Fernández-Soria S. Ramón y Cajal |
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| Affiliation: | (1) Department of Comparative Pathology, Veterinary School, University of Córdoba, C, órdoba, Spain;(2) Department of Pathology, Clínica Puerta de Hierro, Madrid, Spain |
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| Abstract: | Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification. |
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| Keywords: | animal models canine carcinoma chromogenic in situ hybridization immunohistochemistry mammary gland oncogene HER-2 |
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