口服猪脾来源免疫抑制组分抗炎作用的实验研究

 目的研究口服Mr小于5000的猪脾来源免疫抑制组分（SISC-p）的抗炎作用。方法通过给动物ig SISC-p，观察其对巴豆油致小鼠耳廓肿胀和对大鼠棉球肉芽肿的影响。结果ig SISC-p一次给药对巴豆油致小鼠耳廓肿胀没有影响，多次给药在一定剂量（10mg·kg^-1）则有显著的抑制作用（P＜0.05）；在实验剂量（16,8和4 mg·kg^-1）下，SISC-p对大鼠棉球肉芽肿均有显著的抑制作用，其中高剂量和中剂量的作用效果较好。结论ig SISC-p多次给药对急性炎症和亚急性炎症均有对抗作用。

Experimental studies on the anti-inflammatory effect of immunosuppressivecomponent derived from porcine spleen

OBJECTIVE To study the anti inflammatory effect of porcine spleen derived immunosuppressive component(named SISC-p), a fraction with Mr less than 5000. METHODS Different doses SISC-p of were given to animals ig and the effects of it on croton oil caused mouse auricular edema and cotton ball induced granuloma in rats were observed. RESULTS Single dose SISC-p ig had no inhibitory effect on croton oil caused mouse auricular edema,but it produced inhibitory effect when given a certain dose (10 mg·kg^-1) repeatedly for seven days. SISC-p could significantly inhibit cotton ball induced granuloma in rats under the experimental doses（16, 8 and 4mg·kg^-1）.CONCLUSION SISC-p po had inhibitory effects on acute and subacute inflammation.