Absence of the kdr mutation in the molecular 'M' form suggests different pyrethroid resistance mechanisms in the malaria vector mosquito Anopheles gambiae s.s |
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Authors: | Awolola T S Brooke B D Koekemoer L L Coetzee M |
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Institution: | Public Health Division, Nigerian Institute of Medical Research, Lagos, Nigeria. awololas@hotmail.com |
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Abstract: | Field tests conducted on adult Anopheles mosquitoes using standard WHO procedures, diagnostic kits and test papers in south-western Nigeria showed pyrethroid (deltamethrin and permethrin) resistance in adult populations of Anopheles gambiae sensu stricto. The knock-down resistance (kdr) mutation involved in pyrethroid resistance was only found in the molecular S form of An. gambiae s.s. even in area where both molecular M and S forms occurred in sympatry. The absence of the kdr mutation in the M form suggests an additional pyrethroid resistance mechanism in An. gambiae s.s. |
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Keywords: | Anopheles gambiae molecular forms pyrethroid kdr resistance |
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