贵州汉族群体F13A01、FESFPS、vWA基因座遗传多态性研究

目的 了解贵州汉族人群F13A01、FESFPS、vWA的遗传多态性分布，获得这3个多态位点的群体遗传学数据。方法 应用聚合酶链反应复合扩增技术，对160名无血缘关系的汉族个体的F13A01、FESFPS、vWA3个短串联重复序列(short tandem repeats，STlR)基因座等位基因频率进行了分析。结果 3个STR基因座基因频率的分布均符合Hardy—Weinberg平衡，3个STR基因座总个体识别率为0．9984，累积多态信息含量为0．97。结论 所得到的等位基因频率数据可为贵州汉族人群法医个体识别、亲子鉴定及遗传学研究提供更多依据。

Genetic polymorphisms of short tandem repeats loci F13A01, FESFPS, vWA from Han population in Guizhou

Objective To understand the allele structure and genetic polymorphism at F13A01, FESFPS and vWA short tandem repeats (STRs) loci for Han population in Guizhou province of China, and to construct a preliminary database. Methods One hundred sixty unrelated individuals in Han population from Guizhou were analyzed by multiplex polymerase chain reaction. The resultant allele frequencies were compared with those of other population or race database. Results The genotype distributions of F13A01,FESFPS and vWA were in accordance with Hardy-Weinberg equilibrium. The combined discrimination power and polymorphism information content were 0.9984 and 0.97 respectively.Conclusion All of the three loci in this study provide useful markers for forensic paternity test and for genetic purposes.