多西紫杉醇同期放化治疗局部晚期宫颈癌

目的探讨多西紫杉醇同期放化治疗局部晚期宫颈癌疗效和毒副反应。方法多西紫杉醇25mg/(m2?周),每周放疗的第1天同步静脉滴注,常规抗过敏预处理,连续6周;放疗方法:外照射放疗采用直线加速器盆腔大野DT30Gy后中央挡铅改为盆腔四野加量照射至DT50Gy,分割剂量180～200cGy/F,常规分割,盆腔四野照射期间每周局部后装铱192照射1次,每次剂量6Gy,共6次,A点剂量达3600cGy,观察疗效和不良反应。结果多西紫杉醇同期放化组总有效率91%,临床获益率91%;随访12个月无进展生存率(PFS)和总生存率(OS)分别为83%和100%。结论多西紫杉醇同期放化疗效可靠,毒副反应安全可耐受。

The Analysis of Docetaxel Concurrent Chemotherapy and Radiotherapy in Local Advanced Cervical Cancer.

Objective To investigate the effective and toxicity of docetaxel concurrent chemotherapy and radiotherapy in local advanced cervical cancer.Methods Docetaxel given at a dose of 25mg/（m2·w） for 6 cycles during the whole radiotherapy course under the conditions of anti-allergic management.External radiotherapy given at a dose 30Gy firstly and then were irradiated for another 20Gy under the condition of A point shielded plus intracavitary irradiation for 6Gy once a week to a total dose 36Gy for A point.Results The effective rate and clinical benefits rate all were 91%.The 12 months disease-free survival and overall survival were 83% and 100%.Conclusion Docetaxel chemoradiotherapy can get better effection and tolerated side-effection.