| 线粒体DNA与双相障碍发病的相关性研究进展 |
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| 引用本文： | 张 晨 综述,方贻儒 审校.线粒体DNA与双相障碍发病的相关性研究进展[J].上海交通大学学报(医学版),2009,29(8):994. |
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| 作者姓名： | 张 晨 综述 方贻儒 审校 |
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| 作者单位： | 上海交通大学,医学院精神卫生中心,上海200030 |
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| 基金项目： | "十五"国家攻关计划，国家高技术研究发展计划("八六三"计划)，上海市科委基金 |
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| 摘 要： | 线粒体是细胞能量代谢的中心.人体内线粒体DNA突变可导致细胞氧化磷酸化及能量供应异常,可能与双相障碍的发生有关.文章就线粒体DNA与双相障碍发生的相关性研究进行综述.
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| 关 键 词： | 线粒体DNA 双相障碍 突变 |
Research progress of relationship between mitochondrial DNA and bipolar disorder |
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| ZHANG Chen reviewer,FANG Yi-ru reviser.Research progress of relationship between mitochondrial DNA and bipolar disorder[J].Journal of Shanghai Jiaotong University:Medical Science,2009,29(8):994. |
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| Authors: | ZHANG Chen reviewer FANG Yi-ru reviser |
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| Institution: | Shanghai Mental Health Center;School of Medicine;Shanghai Jiaotong University;Shanghai 200030;China |
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| Abstract: | Mitochondria are essential elements that generate energy in cells.Mutations of human mitochondrial DNA may lead to aberrant oxidative phosphorylation and energy supplement in cells,indicating a possible relationship with bipolar disorder.The research progress on relationship between mitochondrial DNA and bipolar disorder is reviewed in this paper. |
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| Keywords: | mitochondrial DNA bipolar disorder mutation |
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