全甲洋参胶囊对环磷酰胺所致小鼠骨髓嗜多染红细胞微核形成率和外周血象的影响

目的 :观察全甲洋参胶囊 (简称全甲洋参 )对环磷酰胺 (Cy)所致小鼠骨髓嗜多染红细胞 (PE)微核形成率及外周血象的影响 ,探讨其临床治疗作用机理。方法 :分别观察单纯给予全甲洋参、单纯给予Cy及Cy加全甲洋参 3种方式对小鼠PE微核形成率和外周血白细胞 (WBC)、红细胞 (RBC)、血红蛋白 (Hb)的影响 ,并与空白对照组、单用Cy组进行对照。 结果 :全甲洋参对正常小鼠PE微核形成率及外周血WBC、RBC、Hb无明显影响 ;Cy组PE微核形成率显著上升 (P <0 0 1) ,WBC、RBC、Hb显著下降 (P <0 0 1) ;Cy加全甲洋参组 (高、中、低剂量 )使PE微核形成率上升及WBC、RBC、Hb下降得到控制 ,Cy加全甲洋参高、中剂量组各项指标与Cy组比较 ,差异均有显著性 (P <0 0 1) ;Cy加全甲洋参低剂量组与Cy组比较 ,除Hb外 ,各指标亦差异有显著性 (P <0 0 1)。结论 :全甲洋参胶囊可拮抗Cy的骨髓抑制作用 ,即对Cy的毒副作用有一定的拮抗性。

Effects of Quanjia Yangshen Capsule on Rate of Polychromatic Erythrocytic Micronucleus Formation and Peripheral Blood Picture in Mice Treated by Cyclophosphamide

Objective: To observe the effect of Quanjia Yangshen capsule (QJYS) on cyclophosphamide (Cy) induced teratogenesis and bone marrow in mice and to explore the mechanism of its clinical therapeutic effect. Methods: Mice were separately administered with QJYS solely, Cy solely and QJYS Cy and the effect on polychromatic erythrocytic (PE) micronucleus formation rate in the bone marrow of mice, and peripheral blood picture were observed and compared with the control group. Results: High dosage of QJYS has no apparent effect on PE micronucleus formation rate and peripheral blood picture in the normal mice; Cy can obviously raise PE micronucleus formation rate (P<0 01), and lowered WBC, RBC and Hb obviously (P<0 01) in mice. After taking QJYS, the Cy induced micronucleus formation rate increasing and blood picture parameters lowering were controlled. The improvement in the high and middle dose QJYS group was significantly higher in comparing to that in the sole Cy group (P<0 01); while the low dose QJYS group in comparing with Cy group also showed significant improvement (P<0 01), except Hb value. Conclusion: QJYS could significantly antagonize teratogenic effect and inhibition to bone marrow of Cy, i.e., play an antagonistic role against the toxic and side effects of Cy.