| 不同剂量维生素K_3对大鼠肾骨桥蛋白表达的影响 |
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| 引用本文： | 施国海,李文峰,张士青. 不同剂量维生素K_3对大鼠肾骨桥蛋白表达的影响[J]. 中华泌尿外科杂志, 2006, 0(Z2) |
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| 作者姓名： | 施国海 李文峰 张士青 |
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| 作者单位： | 上海交通大学附属上海第三人民医院泌尿外科，上海交通大学附属上海第三人民医院泌尿外科，上海交通大学附属上海第三人民医院泌尿外科 |
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| 基金项目： | 上海自然科学基金资助项目(024119087) |
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| 摘 要： | 目的探讨不同剂量的维生素K3对大鼠肾骨桥蛋白(osteopontin,OPN)表达分布的影响。方法对饮用相同诱石剂的50只大鼠分6组分别给予4.0、3.0、2.0、0.8mg/d和0.4mg/d剂量的维生素K3,观察肾OPN表达分布变化。结果正常饮食鼠肾OPN表达部位集中在远曲小管,应用诱石剂后OPN表达部位扩展到近曲小管,维生素K3能够减少OPN表达量,随着维生素K3剂量由0.4mg/d增加到4mg/d,肾脏OPN表达量从(70±22)%逐渐减少到(20±8)%。结论维生素K3可减少诱石剂导致的肾曲小管OPN表达分布的变化。
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| 关 键 词： | 维生素K_3 肾结石 骨桥蛋白 |
Different doses of vitamin K3 effect the expression of OPN of rats kidney |
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| SHI Guo-hai,LI Wen-feng,ZHANG Shi-qing. Different doses of vitamin K3 effect the expression of OPN of rats kidney[J]. Chinese Journal of Urology, 2006, 0(Z2) |
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| Authors: | SHI Guo-hai LI Wen-feng ZHANG Shi-qing |
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| Affiliation: | SHI Guo-hai,LI Wen-feng,ZHANG Shi-qing. Department of Urology,the third Affiliated Hospital,shanghaijiaotong university,Shanghai 200025,China |
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| Abstract: | Objective To investigate the effect of different doses of Vitamin K3 on the expression of osteopontin in rats kidney. Methods After different dose of Vitamin K3 were injected to different groups of rats feeded with same stone-inducing agent, the level of expression of OPN in renal tissues was observed with immunohistological staining. Results OPN expression located at distal convoluted tubule when the rats feeded without stone-inducing agent, and the OPN expression stain was extended to proximal convoluted tubule when the stone-inducing agent was feeded. Vitamin K3 can decrease the extension of OPN expression induced by the agent and more doses of Vitamin K3, more effects. Conclusions Vitamin K3 can decrease the expression of OPN in the kidney tubule of rats feeded with stone-induced agent. |
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| Keywords: | Vitamin K3 Renal calculus Osteopontin(OPN) |
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