头孢吡肟治疗老年下呼吸道感染疗效及安全性评价

目的评价头孢吡肟治疗80岁以上老年人下呼吸道感染的临床疗效、细菌耐药及安全性。方法采用回顾性研究,用头孢吡肟1-2g,静脉滴注,每12h一次,治疗80岁以上老年中、重症下呼吸道感染65例,观察疗效、细菌耐药及安全性(特别是肾功能的变化)。结果用药后临床有效率、临床痊愈率和细菌清除率依次为 70．77％、53．85％、71．8％;110株细菌高敏率、敏感率和耐药率分别为63．6％、75．5％、24．5％;出现不良反应 19例,其中6例腹泻、9例并发真菌感染,用药后有2例血肌酐升高,4例肌酐清除率下降,其中1例肌酐清除率明显下降;未发现其他副作用。结论头孢吡肟是一个有效的治疗80岁以上老年下呼吸道感染的抗菌药物,但因耐药菌株也在不断增加,故应密切监测致病菌耐药性的产生和变化,同时,要根据肌酐清除率选择用药剂量,并密切观察肾功能的变化,及时调整治疗方案。

Efficacy and safety evaluation of Cefepime for the treatment of elderly patients with lower respiratory tract infection

Objective To evaluate the efficacy and safety and antimicrobial resistance of cefepime for the treatment of elderly patients with lower respiratory tract infection. Methods A total of 65 patients with lower respiratory tract infection were treated with cefepime (1.0-2.0g/day iv q12h) in an open clinical study. Results The total efficacy rate of cefepime was 70.77%. with cure rate of 53.85%. bacteria elimination rates were 71.8%. The hight sensitive rate was 63.6%, The moderate sensitive rate was 75.5%, The resistance rate was 24.5%, adverse events was 29.2% (19/65). Conclusions The study shows that cefepime is well tolerated and effective in treating lower respiratory tract infection of elderly patients .