Placental expression of insulin-like growth factor-I,fibroblast growth factor-basic,and neural cell adhesion molecule in preeclampsia |
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Authors: | Dr Sebi˙ha Özkan Bi˙rol Vural Serdar Fi˙li˙z Peli˙n Coştur Hakki Dalçik |
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Affiliation: | 1. Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University, Kocaeli, Turkeysozkan1972@yahoo.com;3. Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University, Kocaeli, Turkey;4. Department of Histology and Embryology, School of Medicine, Kocaeli University, Kocaeli, Turkey |
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Abstract: | Objective. To investigate placental expression of insulin-like growth factor-I (IGF-I), fibroblast growth factor-basic (FGF-b), and neural cell adhesion molecule (N-CAM) in preeclampsia.Study design. An immunohistochemical analysis using IGF-I, FGF-b, and N-CAM antibodies was conducted on 4% paraformaldehyde-fixed placental tissues of preeclamptic patients (N = 14) and normotensive pregnant subjects (N = 10). Immunostaining patterns of chorionic villi and amniochorionic membranes were assessed.Results. Significantly increased FGF-b and N-CAM immunoreactivities in cytotrophoblasts and increased FGF-b immunoreactivity in capillary endothelium of chorionic villi of preeclamptic subjects were noted. Significantly increased FGF-b and decreased N-CAM immunoreactivities in extravillous trophoblasts and decidual cells of amniochorionic membranes obtained from preeclamptic subjects were demonstrated. Additionally, a significantly increased IGF-I immunoreactivity was shown in decidual cells of preeclamptic cases.Conclusion. Investigation of the regional distribution of IGF-I, FGF-b, and N-CAM at the maternal–fetal interface establishes a better understanding of cell-specific altered growth processes, which may be associated with the pathogenesis of preeclampsia. |
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Keywords: | Insulin-like growth factor fibroblast growth factor-basic neural cell adhesion molecule placenta preeclampsia |
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