| LC-MS/MS法测定产妇乳汁中舒芬太尼的浓度 |
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| 引用本文： | 林红,高芳芳,黄秀旺,黄仰发.LC-MS/MS法测定产妇乳汁中舒芬太尼的浓度[J].中国药物依赖性杂志,2019(1):24-29. |
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| 作者姓名： | 林红 高芳芳 黄秀旺 黄仰发 |
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| 作者单位： | 1.福建省食品药品质量检验研究院;2.福建中医药大学;3.福建医科大学公共技术中心;4.福建医科大学附属协和医院 |
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| 基金项目： | 福建省卫计委青年项目(2015-1-36) |
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| 摘 要： | 目的:测定产妇经静脉输注泵给予舒芬太尼的镇痛期间和镇痛结束后不同时间点的乳汁药物浓度,为临床产后镇痛过程中的母乳喂养安全性研究提供测定方法与参考。方法:采用梯度洗脱,ESI离子源,使用正离子模式,多反应离子监测(MRM),液-液萃取法,加入正己烷和乙酸乙酯(1:9,V/V)提取。结果:在3. 2-400 pg·mL-1的线性关系良好(R2=0. 998),定量下限为3. 2 pg·mL-1,提取回收率在83. 1%-100. 7%。样品测得的最低浓度(停药22 h)为4. 75 pg·mL-1,最高浓度(用药31 h)为196. 74 pg·mL-1。持续镇痛24 h后,药物浓度在27. 19-196. 74 pg·mL-1之间;停药后2-20 h,乳汁中的药物浓度在7. 88-21. 58 pg·mL-1之间,停药超过20 h的药物浓度在4. 75-19. 22 pg·mL-1之间。结论:建立LC-MS/MS法检测,灵敏度高、速度快、操作简单、抗干扰能力强,可准确测定乳汁中微量的舒芬太尼药物浓度。
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| 关 键 词： | 舒芬太尼 乳汁药物浓度 LC-MS/MS |
Determination of the sufentanil in parturient women breast milk by LC-MS/MS |
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| LIN Hong,GAO Fangfang,HUANG Xiuwang,HUANG Yangfa.Determination of the sufentanil in parturient women breast milk by LC-MS/MS[J].Chinese Journal of Drug Dependence,2019(1):24-29. |
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| Authors: | LIN Hong GAO Fangfang HUANG Xiuwang HUANG Yangfa |
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| Institution: | (Fujian Institute for Food and Drug Quality Control, Fujian, 350001, China;Fujian University of Traditional Chinese Medicine, Fujian , 350122 , China;ore Facility of Fujian Medical University, Fujian , 350108, China;Fujian Medical University Union Hospital, Fujian , 350001, China) |
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| Abstract: | LIN Hong;GAO Fangfang;HUANG Xiuwang;HUANG Yangfa(Fujian Institute for Food and Drug Quality Control, Fujian, 350001, China;Fujian University of Traditional Chinese Medicine, Fujian , 350122 , China;ore Facility of Fujian Medical University, Fujian , 350108, China;Fujian Medical University Union Hospital, Fujian , 350001, China) |
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| Keywords: | Sufentanil concentration in breast milk LC - MS/MS |
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