Evaluation of a rapid optical immunoassay-based test for group B streptococcus colonization in intrapartum patients |
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Authors: | Cora W Ngai William L Martin Ann Tonks Michael P Wyldes Mark D Kilby |
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Institution: | 1. Department of Fetal Medicine, Division of Reproduction &2. Child Health, Birmingham Women's Hospital, USAbill.martin@bwhct.nhs.uk;4. Child Health, Birmingham Women's Hospital, USA;5. West Midland Perinatal Institute, Birmingham, UK |
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Abstract: | Objective.?To investigate the association between cleft lip and/or palate and perinatal mortality.Methods.?A retrospective review was performed of cases of cleft lip/palate born to West Midlands residents from 1995 to 1997. Perinatal mortality for identified cases was compared with all births from 1995 to 1997.Results.?347 cases of cleft lip and/or cleft palate were delivered from 1995 to 1997. Thirty-six pregnancies were terminated due to parental wishes - 2 were registerable births. There were 310 spontaneous registerable births (stillbirths/livebirths) with cleft lip and/or palate and 1 further late fetal loss. In 220 (70.5%), the lesion was isolated. Of these, there were 7 perinatal deaths, 5 had post mortems and no additional anomalies were identified. In 92 (29.5%) cases other abnormalities were identified. The overall perinatal mortality rate (PNMR) in the West Midlands, was 10.0/1000 total births. The overall PNMR for babies with facial clefts was 89.7/1000 total births. The PNMR for those with associated anomalies was 228.3/1000 live/still births. The PNMR for isolated facial clefts was 31.8/1000 live/still births, significantly higher than the background population (OR 3.3, 95% CI: 1.5–7.0).Conclusion.?Consideration should be given to screening the fetus at 20–24 weeks for facial deformity. This has implications for detection both of fetal anomalies and of a population at risk for adverse outcome. |
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Keywords: | Clefts perinatal mortality |
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