Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy |
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| Authors: | Michal Kovo Ariel Weissman Dvir Gur David Levran Sigi Rotmensch Marek Glezerman |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israelmichalkovo@hotmail.com;3. Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel;4. IVF Unit, The Edith Wolfson Medical Center, Holon, Israel |
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| Abstract: | Objective.?The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.Method.?Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case–control study.Results.?The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.Conclusion.?Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy. |
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| Keywords: | Birth weight percentile pregnancy complications |
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