153钐-乙二胺四甲基膦酸治疗多发性骨转移癌骨痛疗效观察

目的 探讨^153钐－乙二胺四甲基膦酸（^153Sm-EDTMP）核纱治疗多发性骨转移癌的可行性。方法 静脉注射^153Sm-EDTMP32例，每疗程剂量0.4-1.0mci/kg(1mCi=37MBq），肝静脉一次注入，其中7例接受2－3次治疗。结果 骨痛完全缓解53.1％（17／32），部分缓解25.0％（8／32），轻度缓解9.4%（3／32），无效12.5％（4／32），总有效率为78.1％。副作用为WBC和（或PLT的Ⅰ度、Ⅱ度下降，占15.6％（5／32），6－8周内基本恢复至治疗前水平。结论 ^153Sm-EDTMP治疗骨广泛转移癌，止痛效果确切，副作用小。

Clinical observation of multiple bone metastases with153Sm-EDTMP

Objective To evaluate the feasibility of 153　Sm-EDTMP for multiple bone metastasis.Methods 32 patients with multiple bone metastases were treated with 153　Sm-EDTMP injected into the veins,0.4～1.0 mci/kg,of which 7 cases received therapy for 2～3 times.Results 53.1%(17/32)was relieved completely,25.0%(8/32)was relieved partially and 9.4%(3/32)was relieved slightly.No effects were found in 12.5%(4/32).The overall effective rate was 78.1%.Side effects that were the decreasing of WBC and PLT were found in 15.6%(5/32),which rose to the preoperative levels within 6～8 weeks.Conclusion Internal radiotherapy with 153　Sm-EDTMP is safe and effective in the treatment of multiple bone metastases.