新生儿脐血砷、硒水平与新生儿生长指标关系的研究

目的:以脐血砷、硒水平为指标,探讨两种元素对于新生儿生长发育的影响。方法:选择在该院出生的足月新生儿213例作为研究对象,采集新生儿脐带血并测定脐血砷和脐血硒。结果:脐血砷水平与新生儿体重及身长的相关性不明显,差异无统计学意义(体重:r=-0.031,P=0.682;身长:r=-0.082,P=0.253)。而脐血砷水平与头围呈正相关,差异有统计学意义(r=0.322,P=0.000),脐血硒水平与体重和身长的相关性不显著,差异无统计学意义(体重:r=0.343,P=0.062;身长:r=0.295,P=0.081)。而脐血硒水平与头围呈负相关,差异有统计学意义(r=-0.413,P=0.000),新生儿头围与脐血砷水平存在正相关(β=0.08,P=0.00),与脐血硒水平的相关性无明显统计学意义(β=-0.03,P=0.31)。结论:新生儿脐血砷水平对于新生儿的生长发育存在负面影响,而微量元素硒则可能能够拮抗这种不良么应。

Research on the relationship between umbilical arsenic, selenium concentrations and neonatal growth indicators

Objective:To explore the effects of arsenic and selenium in umbilical cord blood on neonatal growth and development.Methods:A total of213 full-term neonates in the hospital were selected as study objects.The levels of arsenic and selenium in umbilical cord blood of the neonates were collected and detected.Results:The correlation between the arsenic concentration in umbilical cord blood and neonatal weight and length was not obvious,there was no statistically significant difference(weight: γ=-0.031,P=0.682;height:γ=-0.082,P=0.253).But the arsenic concentration in umbilical cord blood was positively correlated with head circumference,there was statistically significant difference(γ=0.322,P=0.000).The correlation between selenium concentration in umbilical cord blood and neonatal weight and length was not obvious,there was no statistically significant difference(weight: γ=0.343,P=0.062;height: γ=0.295,P=0.081).But the selenium concentration in umbilical cord blood was negatively correlated with head circumference,there was statistically significant difference(γ=-0.413,P=0.000).The neonatal head circumference was positively correlated with arsenic concentration in umbilical cord blood(β=0.08,P=0.00),but there was no correlation between neonatal head circumference and selenium concentration in umbilical cord blood(β=-0.03,P=0.31).Conclusion:The arsenic concentration in umbilical cord blood has negative impact on neonatal growth and development,while selenium might antagonize this side effect.