三阴性乳腺癌治疗进展

三阴性乳腺癌(TNBC)是乳腺癌中恶性程度最高的分子亚型,具有侵袭性强,易于早期复发转移,高异质性等特点.目前化疗仍然是TNBC的标准系统治疗方案,但随着组学技术的高速发展,研究者对TNBC分子生物学本质认识不断加深,发现可以将其分为多种亚型,根据各种分型的生物学特征进行分类治疗,同时针对肿瘤细胞自身特征与外部微环境特...

Advances in treatment of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with highly aggressive and heterogenous nature and a tendency towards early recurrence and metastasis. At present, chemotherapy remains the standard treatment of TNBC. However, with the rapid development of omics technologies and the increasing deepening of understanding towards the molecular biologic features of TNBC, researchers found that it is possible to classify TNBC into several subtypes, and to perform tailored treatment strategies based on the specific characteristics of its subtypes, and meanwhile to develop target drugs through discovering the novel therapeutic targets based on both intrinsic signals and extrinsic microenvironment of the cancer cells, and finally to add them into standard regimen after translational clinical trials. Targeted therapies based on molecular subtypes may become the future direction of precision treatment for TNBC.