|
|||||
|
|
Time since last vaccine dose in PCR-positive and PCR-negative children with suspected pertussis to monitor pertussis vaccine effectiveness |
|
| Authors: | M. Riffelmann J. Mohr W. Hellenbrand C. H. Wirsing von Koenig |
| Affiliation: | 1. Labor:Medizin Krefeld Medizinisches Versorgungszentrum GmbH, Lutherplatz 40, 47805, Krefeld, Germany 2. Institut für Hygiene und Labormedizin, HELIOS Klinikum Krefeld, Krefeld, Germany 3. Zentrum für Kinder- und Jugendmedizin, HELIOS Klinikum Krefeld, Krefeld, Germany 4. Abteilung für Infektionsepidemiologie, Robert-Koch-Institut, Berlin, Germany |
| Abstract: | We evaluated whether the results of diagnostic polymerase chain reaction (PCR) testing combined with time since last vaccine dose could be used to monitor the effectiveness of acellular pertussis vaccines. In 258 consecutive nasopharyngeal swabs from children and adolescents with typical pertussis symptoms, 80 were positive and 178 were negative in PCR for Bordetella pertussis DNA (IS 481). Time since last vaccine dose was available for 152 patients, of which 120 were fully immunised. Among the fully vaccinated patients, the median age of 41 PCR-positive patients was 8.4 years (range 0.9–12.3) and that of 79 PCR-negative cases was 3.3 years (range 0.4–14.1) (p?p? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |