萘酰亚胺类纳米杂化荧光探针的制备及性能

利用两亲性嵌段共聚物聚苯乙烯-b-聚丙烯酸(PS-b-PAA)的自组装行为及有机硅烷偶联剂3-巯基丙基三甲氧基硅烷(MPTMS)水解自缩聚的特性,制备了一系列包裹疏水性萘酰亚胺类荧光分子(DPN)的纳米杂化荧光探针(DPN@HNP)。系统地研究了DPN的包裹量、嵌段共聚物及硅烷偶联剂对DPN@HNP的光物理性能及形貌的影响。结果表明,DPN包裹量增加或堆叠紧密会使紫外-可见光吸收与荧光发射强度提高并发生红移;嵌段共聚物链段长度与用量增加,使更多的DPN分子被包裹,从而获得更高的荧光强度与更大的粒径;偶联剂包覆有机硅层会加剧DPN分子的堆叠紧密程度,从而提高纳米探针的荧光强度,而其添加量与反应时间对荧光探针的光物理特性影响不大。

Synthesis and Properties of Napthalimide-Derivatives-Encapsulated Hybrid Fluorescent Nanoprobes

A series of hybrid fluorescent nanoprobes (DPN@HNP) encapsulating hydrophobic napthali-mide derivatives N-dodecyl-4-piperidyl-1, 8-napthalimide(DPN) were prepared based on the self-assembly of amphiphilic block copolymer polystyrene-b-poly(acrylic acid)(PS-b-PAA) and the hydrolysis of organic silane 3-mercaptopropyltrimethoxy-silane (MPTMS). The influences of the loading amounts of DPN, block copolymer and organic silane on the photophysics properties and morphology of the as-synthesized DPN@HNP were comprehensively investigated. Results show that the absorption and emission spectra of DPN@HNP intensifies and red-shifts with the increase of loading amount and the degree of packing of DPN. The length of PS segment and adding amount of PS-b-PAA have a significant effect on the loading amount and the efficiency of DPN. Both longer PS segment and higher adding amount lead to higher loading amount of DPN and larger diameter of DPN@HNP, thus enhance the emission. The adding amount and reaction time of MPTMS have negligible effects on the photophysics properties of DPN@HNP, while the hybrid silica shell thicken with the increase of the adding amount of MPTMS.