| 多重响应的单分散聚(N-异丙基丙烯酰胺-co-丙烯酸)纳米水凝胶的制备及性能表征 |
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| 引用本文： | 马天泽,李雪婷,赵迪,安冬,石小迪,鲁希华.多重响应的单分散聚(N-异丙基丙烯酰胺-co-丙烯酸)纳米水凝胶的制备及性能表征[J].医学教育探索,2015,28(3):307-312. |
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| 作者姓名： | 马天泽 李雪婷 赵迪 安冬 石小迪 鲁希华 |
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| 作者单位： | 东华大学化学化工与生物工程学院, 上海 201620;东华大学化学化工与生物工程学院, 上海 201620;东华大学化学化工与生物工程学院, 上海 201620;东华大学化学化工与生物工程学院, 上海 201620;东华大学化学化工与生物工程学院, 上海 201620;东华大学化学化工与生物工程学院, 上海 201620;东华大学材料科学与工程学院纤维材料改性国家重点实验室, 上海 201620 |
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| 基金项目： | 国家自然科学基金(51473032);上海科委国际合作项目(13520720100) |
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| 摘 要： | 以N-异丙基丙烯酰胺(NIPAM)与丙烯酸(AA)为单体,在水相中通过乳液聚合法制得具有温度、pH双重响应的单分散聚(N-异丙基丙烯酰胺-co-丙烯酸)(P(NIPAM-co-AA))纳米水凝胶。利用动态光散射仪(DLS)、原子力显微镜(AFM)和傅里叶红外光谱仪(FT-IR)对纳米水凝胶的尺寸、形貌和化学组成进行了表征,讨论了单体含量和乳化剂含量对凝胶粒径和多分散指数(PDI)的影响,同时探究了纳米水凝胶的温敏性和pH敏感性。结果表明:当AA为单体总物质的量分数的20%、乳化剂用量为0.05 g时,制得的球形纳米水凝胶形态均匀规整,水合直径为403 nm,PDI仅为0.033,且对温度和pH具有双重敏感,尤其在pH为4~6时,响应极为明显。
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| 关 键 词： | N-异丙基丙烯酰胺 丙烯酸 分散性 纳米水凝胶 |
| 收稿时间： | 2015/5/30 0:00:00 |
Preparation and Performance Characterization of Multiple Responsive and Monodisperse Poly(N-isopropylacrylamide-co-acrylic acid) Nanogels |
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| MA Tian-ze,LI Xue-ting,ZHAO Di,AN Dong,SHI Xiao-di and LU Xi-hua.Preparation and Performance Characterization of Multiple Responsive and Monodisperse Poly(N-isopropylacrylamide-co-acrylic acid) Nanogels[J].Researches in Medical Education,2015,28(3):307-312. |
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| Authors: | MA Tian-ze LI Xue-ting ZHAO Di AN Dong SHI Xiao-di and LU Xi-hua |
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| Institution: | College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China |
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| Abstract: | The thermo- and pH- sensitive monodisperse poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) nanogel was prepared through emulsion polymerization in aqueous solution using N-isopropylacrylamide (NIPAM) and acrylic acid (AA) as monomers. The hydrogels structure and chemical compositions were characterized by Dynamic Light Scattering (DLS), Atomic Force Microscope (AFM) and Fourier Transform Infrared (FT-IR). The influence of the contents of monomer and emulsifier on the particle size and polydispersity index (PDI) of the hydrogels were studied, and the thermo- and pH- sensitiveness of the nanogel were explored. When the molar ratio of AA to monomer was 20% and the mass of emulsifier was 0.05 g, the synthesized nanogel particle morphology was uniform and neat with the hydrated particle size 403 nm and PDI only 0.033, and the nanogel was sensitive to temperature and pH, especially for pH of 4-6. |
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| Keywords: | N-isopropylacrylamide acrylic acid dispersivity nanogel |
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