心理行为干预对乳腺癌新辅助化疗患者情绪及免疫功能的影响

目的了解心理行为干预对乳腺癌新辅助化疗患者情绪及免疫功能的影响。方法对20例乳腺癌新辅助化疗患者，在新辅助化疗期间进行心理行为干预，采用Zung’s抑郁自评量表、Zung’s焦虑自评量表测定情绪反应，采用流式细胞仪测定外周血总T细胞亚群（CD3）、辅助T细胞（CD4^＋）、抑制T细胞（CD8^＋），研究干预前后患者情绪反应和免疫功能的变化。结果乳腺癌新辅助化疗患者在心理行为干预后，焦虑和抑郁水平下降（P〈0．05）。心理行为干预加化疗后CD4^＋较化疗前升高（P〈0．05）；CD3升高但差异无统计学意义（P〉0．05），CD8^＋虽有下降，但仍在正常范围（P〉0．05）。结论心理行为干预有利于降低乳腺癌新辅助化疗患者焦虑和抑郁水平，提高患者的免疫机能。

Influence of Psychological and Behavioral Intervention on the Emotion and Immune Function of Patients Undergoing Breast Cancer Neo-adjuvant Chemotherapy

Objective To learn about the influence of psychological and behavioral intervention on the emotion and immune function of patients undergoing breast cancer neo-adjuvant chemotherapy. Methods 20 patients undergoing the chemotherapy were offered psycho-logical and behavioral intervention during the chemotherapy. The patients＇ emotional response were tested by means of Zung＇s Self-rating Anxiety Scale and Zung＇s Self-rating Depression Scale, and the count of peripheral Blood lymphocytes, and T cell subsets, was determined by means of flow eytometry, and their emotional responses and immune functions before and after the intervention were studied. Results After the intervention, the patients＇ anxiety and depression diminished （P〈0.05）, CD4^＋ increased （P〈0.05）, the count of peripheral blood lymphocytes rose but not markedly （P〉0.05）, CD8^＋ declined, yet still within the normal range （P〉0.05）. Conclusion Psychological and behavioral intervention are conductive to lowering patients＇ level of anxiety and depression and improving their immune functioning.