微生物感染、炎症与动脉粥样硬化

微生物感染参与动脉粥样硬化的形成过程，从而成为缺血性心、脑血管病的新的危险因子。本文概括近年来国内外关于肺炎衣原体，幽门螺杆菌以及病毒感染(包括CMV、EBV、HIV、柯萨奇B、单纯疱疹和风疹病毒等)促动脉粥样硬化的证据。这些证据包括自动脉斑块处用先进手段检出病原体的抗原或核酸；患者血清中抗体水平；患者血清中的炎症标志物，动物试验结果以及抗微生物感染治疗效果等。同时指出围绕此问题的争论和有待解决的疑点。

Microbial infection,inflammtion and atherosclerosis

Microbial infection and inflammtion involved in the formation process of atherosclerosis and became a new risk factor of ischemic heart and brain vessels diseases. A brief introduction was given to summarize the recent new evidences about the C.pneumoniae. H.pylori. and viruses (including CMV,EVB,HIV,CBV,HSV and Rubella virus)infection enhanced the atherosclerosis . These evidences included the detection of pathogen's antigen or nucleic acid from the plaques of atherosclerosis, the antibodies and inflammtory markers in patient's sera,the animal models and the effects of experimental treatment.The conflicts and problems to be solved about this subject were also mentioned.