难溶性药物的制剂增溶技术及应用

目的：综述难溶性药物增溶和提高生物利用度的制剂技术及应用。方法：查阅国内外相关文献进行总结、归纳。结果：难溶性药物随着制剂技术的改进及新剂型的应用，可通过环糊精包合或复合、固体分散体、微粉化、加增溶剂或助溶剂、成盐处理等多种途径来提高药物的溶出速率和生物利用度。结论：随着药学领域中新制剂技术的发展、新材料的应用，难溶性药物的吸收差、生物利用度低这一限制已逐渐被克服，难溶性药物也可获得较好的吸收和生物利用度。

Solubilizing techniques and their applications to water-insoluble drug preparations

Objective:To review the sloubilizing and bioavailability-enhancing techniques and their applications to the water-insoluble drugs.Methods:Related literature was retrieved and analyzed.Results:The means which can improve the in-vitro solubility and the bioavailability of water-insoluble drugs include:cyclodextrin inclusion or complex,solid dispersion,micronization,solubilizer adding,salt forming,et al.Conclusions:With the development of the novel preparation technology and the applications of new materials,t...