| 褪黑激素、5-羟色胺对大鼠中脑导水管周围灰质薄片神经元自发单位放电的影响(英文) |
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| 引用本文： | 晁东满,张烈雄. 褪黑激素、5-羟色胺对大鼠中脑导水管周围灰质薄片神经元自发单位放电的影响(英文)[J]. 中国神经科学杂志, 1998, 0(1) |
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| 作者姓名： | 晁东满 张烈雄 |
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| 作者单位： | 华东师范大学生物系!上海200062 |
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| 摘 要： | 运用细胞外电生理记录方法，研究了褪黑激素（MEL）、5一羟色胺（5－HT）对大鼠中脑导水管周围灰质（PAG）薄片神经元自发放电的影响。PAG神经元对MEL和5－HT的主要反应分别为抑制和兴奋。MEL的效应能被5－HT的拮抗剂噻庚啶（CPD）所阻断。结果提示，MEL不仅能通过自身受体，而且部分通过5－HT受体起作用。
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| 关 键 词： | 中脑导水管周围灰质薄片 褪黑激素 5-羟色胺 自发单位放电 |
EFFECTS OF MELATONIN, 5-HYDROXYTRYPTAMINE ON THE SPONTANEOUS UNIT DISCHARGES OF MIDBRAIN PERIAQUEDUCTAL GRAY NEURONS IN THE RAT BRAIN SLICES |
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| Chao Dongman, Zhang Liexiong. EFFECTS OF MELATONIN, 5-HYDROXYTRYPTAMINE ON THE SPONTANEOUS UNIT DISCHARGES OF MIDBRAIN PERIAQUEDUCTAL GRAY NEURONS IN THE RAT BRAIN SLICES[J]. Neuroscience Bulletin, 1998, 0(1) |
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| Authors: | Chao Dongman Zhang Liexiong |
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| Abstract: | Using the technique of extracellular elettropbysiological record, we observed the effectS ofmelatonin(MEL), 5-bydroxytryptumine (5-HT) on the spontaneous unit discharges or ueuroas in the ratmidbrain perisqweductal gray (PAC) slices. The dominant responses of PAG neurons to MEL and 5-HT wereinhibitory and excitatory respectively. The effects of MEL could be blocked by cyprohetadine(CPD), one orthe 5-HT receptor antagonists. The results indicated that MEL could modify oeuronal attivity by acting on itsown receptors, and partially by S-HT receptors in PAG. |
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| Keywords: | periaqueuctal gray slice melatonin 5-hydrotryptamine spontaneous unit discharges |
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