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| 聚谷氨酸苄酯/聚乙二醇嵌段共聚物膜的血液相容性研究 | |
| 引用本文： | 王琴梅,滕伟,潘仕荣,张静夏. 聚谷氨酸苄酯/聚乙二醇嵌段共聚物膜的血液相容性研究[J]. 生物医学工程学杂志, 2005, 22(1): 66-69 |
| 作者姓名： | 王琴梅 滕伟 潘仕荣 张静夏 |
| 作者单位： | 1. 中山大学,附属一院,人工心研究室,广州,510080;南开大学,生物活性材料教育部重点实验室,天津,300071 2. 中山大学,附属光华口腔医学院,广州,510080 3. 中山大学,附属一院,人工心研究室,广州,510080 4. 中山大学,基础医学院,化学教研室,广州,510089 |
| 基金项目： | 广东省自然科学基金项目 (0 3 1684)，高等学校重点实验室访问学者基金资助 (2 0 0 0 12 3 ) |
| 摘 要： | 使用凝血时间实验、血小板的黏附和变形实验、血浆蛋白的吸附实验来评价聚谷氨酸苄酯 /聚乙二醇(PBL G/PEG)嵌段共聚物膜的血液相容性 ,PEG嵌段的引入对共聚物血液相容性的影响。结果表明 ,均聚物的血液相容性优于玻璃和硅油 ,共聚物的血液相容性优于均聚物 ,且随着 PEG含量增加 ,其血液相容性更好。 |
| 关 键 词： | 膜 血液相容性 聚谷氨酸苄酯 聚乙二醇 嵌段共聚物 |
| 收稿时间： | 2003-04-28 |
| 修稿时间： | 2003-04-282003-09-14 |
Blood Compatibility of Block Copolymer Membranes of Poly(benzyl L-glutamate)/Poly(ethylene glycol) |
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| Wang Qinmei,Teng Wei, Pan Shirong, Zhang Jingxia. Blood Compatibility of Block Copolymer Membranes of Poly(benzyl L-glutamate)/Poly(ethylene glycol)[J]. Journal of biomedical engineering, 2005, 22(1): 66-69 | |
| Authors: | Wang Qinmei Teng Wei Pan Shirong Zhang Jingxia |
| Affiliation: | 1. Artificial Heart Lab, First Affiliated Hospital,Zhongshan University, Guangzhou 510080,China; 2 . Bioactive Materials Key lab of Ministry of Education, Nankai University, Tianjin 300071,China; 3.Guanghua Stomatological Affiliated Hospital,Zhongshan University, Guangzhou 510080,China; 4 .Chemistry Department, Medical School, Zhongshan University, Guangzhou 510080,China |
| Abstract: | The blood compatibility of block copolymer membranes of poly(benzyl L-glutamate)/poly(ethylene glycol) and the effect of on the blood compatibility of copolymer were evaluated by the clotting time test, the platelet adhesion and deformation test, and the protein adsorption test. The results showed that in terms of blood compatibility, homopolymer was better than glass and silicone, copolymer was better than homopolymer, and the more the PEG in the copolymer, the better the blood compatibility. |
| Keywords: | Membrane Blood compatibility Poly(benzyl L-glutamate) Poly(ethylene glycol) Block copolymer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |