| 免疫介导的运动神经元损伤SMI-31表达的特征 |
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| 引用本文： | 刘亚玲,郭艳苏,许蕾,任爱兵,霍会永,李春岩.免疫介导的运动神经元损伤SMI-31表达的特征[J].中国神经精神疾病杂志,2007,33(2):96-99. |
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| 作者姓名： | 刘亚玲 郭艳苏 许蕾 任爱兵 霍会永 李春岩 |
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| 作者单位： | 河北医科大学第二医院神经内科,石家庄,050000 |
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| 摘 要： | 目的观察实验性自身免疫性灰质病模型中上、下运动神经元磷酸化神经丝表达的特征。方法首先建立实验性自身免疫性灰质病模型,然后,通过免疫组化方法研究免疫介导的神经元损伤过程中运动神经元磷酸化神经丝(SMI-31)表达的变化。结果在免疫介导的神经元损伤过程中,大脑皮层及脊髓前角SMI-31免疫反应阳性的神经元数量与对照组相比明显增加(P=0.000)。结论神经丝重链的异常磷酸化可能在在免疫介导的神经元损伤过程中具有重要的作用。
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| 关 键 词： | 实验性自身免疫性灰质病免疫组化 神经丝 |
| 修稿时间： | 2006年6月13日 |
The SMI-31 expression of motor neuron in immune-mediated injury |
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| LIU Yaling,GUO Yansu,XU Lei,REN Aibing,HUO Huiyong,LI Chunyan.The SMI-31 expression of motor neuron in immune-mediated injury[J].Chinese Journal of Nervous and Mental Diseases,2007,33(2):96-99. |
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| Authors: | LIU Yaling GUO Yansu XU Lei REN Aibing HUO Huiyong LI Chunyan |
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| Abstract: | Objective To observe the expression of phosphorylated neurofilaments of the upper and lower motor neurons in experimental autoimmune gray matter disease (EAGMD) animal model. Methods EAGMD animal model was developed by inoculated guinae pig with bovine spinal cord anterior horn homogenate, and using immunohistochemical(IHC)method, the expression of SMI-31 in motor neuron were observed. Results The numbers of SMI-31 immunoreactive positive spinal cord (SC) motor neuron and cerebral cortex pyramidal cell in EAGMD were obviously increased (P=0.000) than those in controls. Conclusions Abnormal phosphorylation of neurofilament heavy chain (NF-H) may play important role in immune-mediated upper and lower motor neuron injury. |
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| Keywords: | Experimental autoimmune gray matter disease Immunohistochemistry Neurofilament |
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