| p27蛋白在卵巢肿瘤中的表达及临床意义 |
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| 引用本文： | 张永莉,田雪红,荆艳. p27蛋白在卵巢肿瘤中的表达及临床意义[J]. 中国实验诊断学, 2005, 9(6): 904-905 |
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| 作者姓名： | 张永莉 田雪红 荆艳 |
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| 作者单位： | 1. 长春市中心医院,妇产科,吉林,长春,130041
2. 吉林大学第二临床医院,妇产科 |
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| 摘 要： | 目的探讨p27蛋白在卵巢肿瘤中的表达及临床意义。方法采用SP免疫组化的方法对15例良性卵巢肿瘤,45例上皮性卵巢癌对照进行检测,阳性程度用半定量法评价。结果在45例卵巢癌中p27表达阳性反应(57·8%),其中强阳性6例(13·3%),在15例良性卵巢肿瘤中11例呈阳性反应(73·3%),强阳性7例(46·7%),p27表达在良性卵巢肿瘤及恶性卵巢癌对照组比较,两者差异显著(P<0·05)。结论p27与卵巢癌发生、分化程度及淋巴结转移有关,其对临床综合治疗有意义。
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| 关 键 词： | 卵巢癌p27 免疫组织化学 |
| 文章编号： | 1007-4287(2005)06-0904-02 |
| 收稿时间： | 2004-05-17 |
| 修稿时间： | 2004-05-17 |
The expression and clinical significance of p27 in epithelial ovarian cancer |
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| ZHANG Yong-li,TIAN Xue-hong,JING Yan. The expression and clinical significance of p27 in epithelial ovarian cancer[J]. Chinese Journal of Laboratory Diagnosis, 2005, 9(6): 904-905 |
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| Authors: | ZHANG Yong-li TIAN Xue-hong JING Yan |
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| Affiliation: | The Center Hospital of Changchtm City, Changchun 130041, China |
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| Abstract: | Objective To study the expression and clinical significance of p27 in epithelial ovarian cancer. Methods The expression of p27 was observed by immunohistochemical assay in 15 benign ovarian tumors and 45 epithelial ovarian cancer, the extent of expression is evaluated by half-quantitation method. Results The positive rate of p27 expression is 57.8% in epithelial ovarian cancer, 73.3% in epithelial ovarian cancer, the strong expression rate is 13.3% in epithelial ovarian cancer 46.7% in benign ovarian tumors. Conclusion p27 is related to the incidence, differentiation grades and lymphoid metastasis of epithelial ovarian cancer and is useful for compositive clinical therapy. |
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| Keywords: | ovarian carcinoma p27 immunohistochemical |
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