氮气导入中耳腔治疗分泌性中耳炎疗效观察

目的 将氮气(N2)导入分泌性中耳炎患者的中耳腔，希望以此产生并维持长时间的中耳腔正压，达到治疗分泌性中耳炎的目的。方法 用咽鼓管导管吹张法将N2导入20耳分泌性中耳炎患者的中耳腔，用声导抗仪动态观察中耳腔压力的变化，并随访观察患者的症状、体征的变化，判断疗效；将结果与行空气吹张的另20耳分泌性中耳炎作对照组比较。结果 中耳腔在导入N2后能维持较长时间的正压和压力升高。但两组疗效的差别无统计学意义。结论 在治疗分泌性中耳炎时，N2导人中耳腔并未比一般的咽鼓管吹张(空气)显示出更好的疗效。

Efficacy of Middle Ear Inflation with N2 in the Treatment of Otitis Media with Effusion

Objective According to the theory that the rate of nitrogen exchange between middle ear and blood is much slower than oxygen and carbon dioxide, and nitrogen is the major contributor to the total pressure gradient between middle ear and blood, to expect a long duration of positive pressure in middle ear following inflation with nitrogen into middle ear so that contributing to the treatment of otitis media with effusion. Methods After inflation with N 2 into the 20 ears of out-patients who had suffered from otitis media with effusion, the middle ear pressure was recorded immediately and every 2 minutes. Inflation was performed 4 times within 2 weeks duration. Another 20 ears of out-patients who had also suffered from otitis media with effusion inflated with air served as control group. Results ears of N 2 group kept the positive middle ear pressure longer than those of control group. But the efficacy showed no difference between two groups.Conclusion The efficacy of middle ear inflation with N 2 for otitis media with effusion is no better than that of inflation with air.