鲑鱼降钙素配合个体化运动疗法治疗老年性骨质疏松症的临床对照研究

目的:探讨鲑鱼降钙素配合个体化的运动疗法治疗老年性骨质疏松症的临床效果,并比较联合治疗与单纯药物治疗所产生的疗效差异。方法:将150例通过双能X线吸收计量法DXA测定骨密度-2.5同时伴有腰背部疼痛的老年性骨质疏松症患者随机分为3组,对照组;实验1组,对照组+鲑鱼降钙素50 UP肌肉注射,1次/d,连用2周,后改为隔日1次,连续使用3个月;实验2组,实验1组+联合个体化的运动疗法。3组同时每日给予口服钙剂(钙尔奇D)600 mg,1次/d。于治疗前,治疗后7 d、14 d、1月、3月分别观察3组患者的腰背部疼痛变化、骨密度变化及血钙、血磷变化值。结果:随访实验1组、2组均取得良好的镇痛效果,骨密度增强,且实验2组较实验1组骨密度明显增高(P0.05)。结论:鲑鱼降钙素配合个体化的运动疗法治疗老年性骨质疏松症,较传统的治疗方法效果显著,既能预防卧床患者骨质疏松症的发生,又能迅速减轻患者症状,进一步增强骨密度等优点。

Clinic Control Study on the Combination of Salmon Calcitonin and Individualization Exercise Therapy in the Treatment of Senile Osteoporosis

Objective: To explore the clinical result of the combination of salmon calcitonin and individualization exercise therapy in the treatment of Senile Osteoporosis,and to contrast differences between therapeutic alliance and haplo-medication.Methods: 150 cases of osteoporosis accompanied by lumbar back pain with bone mineral density <-2.5 measured by dual energy X-ray absorption measurement method for DXA were randomly divided into three groups,the control group,test group 1 and test grpup 2.The control group was given salmon calcitonin(trade name Miacalcic,made in Beijing Novartis,a bottle of 500 UP),50 UP intramuscular injection,once a day,for 2 weeks;later,once every other day,for 3 months.2 test groups were treated with individual exercise therapy.Calcium(calcium D),600 mg,qd,was oraled for three groups at the same time daily.The changes in lumbar pain,bone mineral density,the level of blood calcium and the phosphorus value were observed before treatment and on the 7th day,14th day,1st month and 3rd month after treatment.Results: The follow-up of the 2 test groups showed that group 1 and group 2 achieved a good analgesic effect,with bone density increased,and the bone density in group 2 was increased more significantly than that in group 1(P<0.05).Conclusion: Compared with the traditionary therapy,the therapeutic alliance of salmon calcitonin and individualization exercise in the treatment of senile osteoporosis is notably effective,which can not only reduce the pain symptom and prevent aggravation of osteoporosis in the patients confined t o bed but also increase bone density.