CC16基因多态性与喉癌的关联研究

目的:检测CC16基因第1外显子38 A/G多态性与喉癌的关系。方法:在30例喉癌患者和30例正常对照中,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对CC16基因第1外显子38位点进行基因分型,分析CC16基因38 A/G多态性与喉癌的关系。结果:病例组和对照组的基因型分布差异具有统计学意义(P=0.031),等位基因分布差异无统计学意义(P0.05)。结论:CC16基因可能与喉癌的发生有关。

A Study on the Relationship between Polymorphism of CC16 and Laryngeal Carainoma

Objective: To detect the polymorphism of 38 A/G in exon 1 of CC16 gene in 30 patients with Laryngeal carainoma.Methods: A case-control study was used to detect the genotypes of 38 A/G in exon 1 of CC16 gene in 30 patients with Laryngeal carainoma and 30 controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).The relationship between polymorphism of CC16 gene and the laryngeal carainoma was analyzed.Results: The significant differences were observed in the frequency of polymorphic genotypes in site 38 in exon 1 of CC16 gene between Laryngeal carainoma and control subjects(P=0.031).There was no significant difference in the frequency of alleles between the both groups(χ2 = 0.137,P> 0.05).No significant differences were observed in the frequency of polymorphic genotypes and alleles in site 38 in exon 1 of CC16 gene with Laryngeal carainoma(P>0.05).There was no significant difference in the frequency of alleles between genders(P>0.05).Conclusion: CC16 gene might be correlated to the occurrence of laryngeal carainoma.