| 胆管癌中VEGF与MMP-9的表达及相关性研究 |
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| 引用本文： | 席量,常亮,王俊飞,樊向文,李尚东,张勇.胆管癌中VEGF与MMP-9的表达及相关性研究[J].包头医学院学报,2012,28(1):52-53. |
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| 作者姓名： | 席量 常亮 王俊飞 樊向文 李尚东 张勇 |
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| 作者单位： | 包钢医院,内蒙古包头,014010 |
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| 摘 要： | 目的:探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在胆管癌中的表达及其相关性。方法:采用免疫组化SP法检测了50例胆管癌及50例正常胆管组织中VEGF及MMP-9的表达。结果:VEGF和MMP-9在胆管癌中的阳性表达率高于正常胆管组织,差异有统计学意义(P<0.01);且胆管癌中VEGF和MMP-9的表达呈正相关。结论:VEGF和MMP-9可能与胆管癌的发生和发展有关,其表达的检测有助于胆管癌的判断。
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| 关 键 词： | 基质金属蛋白酶-9 血管内皮生长因子 胆管癌 |
A Correlative Study of the Expression of VEGF and MMP -9 in Cholangiocarcinoma |
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| Institution: | XI Liang,CHANG Liang,WANG Junfei,et al(The Hospital of Baotou Corporation of Iron and Steel,Baotou 014010,China) |
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| Abstract: | Objective: To evaluate the expression of vascular endothelial growth factor(VEGF) and Matrix metal loproteinases-9(MMP-9) in cholangiocarcinoma.Methods: The expressions of VEGF and MMP-9 were detected by SP immunohistochemical method in 50 cases of cholangiocarcinoma and 50 cases normal bile duct tissues.Results: The positive expression of VEGF and MMP-9 in cholangiocarcinoma tissues was remarkably higher than that in the normal bile duct tissues(P<0.01).The expression of VEGF and MMP-9 was positively related to TNM,mass location,invasion and metastasis in the cholangiocarcinoma(P<0.05).The positive expressions of VEGF and MMP-9 is correlated to each other in cholangiocarcinoma(r =0.326,P<0.05).Conclusion: VEGF and MMP-9 are important factors in infiltration and metastasis of cholangiocarcinoma.The expression detection of VEGF and MMP-9 may help to judge and diagnose cholangiocarcinoma. |
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| Keywords: | VEGF MMP-9 Cholangiocarcinoma |
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