| 虎杖提取物对小鼠急性肝损伤的保护作用 |
| |
| 引用本文： | 鲍红月,陈子越,杨波.虎杖提取物对小鼠急性肝损伤的保护作用[J].海峡药学,2011,23(7):40-42. |
| |
| 作者姓名： | 鲍红月 陈子越 杨波 |
| |
| 作者单位： | 1. 浙江省绍兴市中医院,绍兴,312000
2. 浙江中医药大学,杭州,310053 |
| |
| 摘 要： | 目的观察虎杖提取物对cch诱导的小鼠急性肝损伤的保护作用。方法采用CCl4诱导小鼠急性肝损伤模型，测定血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AsT）、肝组织超氧化物歧化酶（S（）D）活性及丙二醛（MDA）含量。结果cch诱导的小鼠急性肝损伤摸型，血清ALT、AST明显升高，肝组织SOD活性明显降低，MDA含量显著升高（P〈0．01）；虎杖提取物能显著降低血清ALT，AST，明显提高肝组织SOD活性，降低肝组织MDA含量（P〈0．01）。结论虎杖提取物具有降酶及抗氧化的作用。对CCh诱导的小鼠急性肝损伤具有一定的保护作用。
|
| 关 键 词： | 虎杖 四氯化碳 肝损伤 降酶 抗氧化 |
Effect of Polygonum cuspidatum extract on CCl 4 -induced acute liver injury in mice |
| |
| BAO Hong-yue,CHEN Zi-yue,YANG Bo.Effect of Polygonum cuspidatum extract on CCl 4 -induced acute liver injury in mice[J].Strait Pharmaceutical Journal,2011,23(7):40-42. |
| |
| Authors: | BAO Hong-yue CHEN Zi-yue YANG Bo |
| |
| Institution: | 1.Zhejiang Shaoxing tradifional Chinese medicine hospital Shaoxing 312000;2.Zhejiang Chinese Medical University Hangzhou 310053,China) |
| |
| Abstract: | OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4-induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST was significantly increased,liver SOD activity was significantly decreased,MDA content was significantly higher(P<0.01);Polygonum cuspidatum extract significantly decreased serum ALT,AST improve liver SOD activity and lower MDA content in liver tissue(P<0.01).CONCLUSION Polygonum cuspidatum extract has the role of reducing enzyme and antioxidant,on CCl4-induced acute liver injury in mice has a protective effect. |
| |
| Keywords: | Polygonum cuspidatum Carbon tetrachloride Liver injury Lower liver enzymes Anti-oxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
